Skin involvement as the first symptom of rapidly progressive ALK-positive systemic anaplastic large cell lymphoma
Skin involvement as the first symptom of rapidly progressive ALK-positive systemic anaplastic large cell lymphoma
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DOI：
10.1111/ced.13146
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发表时间：
2017-07-01
影响因子：
4.1
通讯作者：
Yao, Z.
中科院分区：
文献类型：
--
作者：
Yu, X.;Zhang, J.;Yao, Z.
系统性间变性大细胞淋巴瘤（sALCL）包括一组相对罕见的T细胞非霍奇金淋巴瘤，其特征是CD 30表达。间变性淋巴瘤激酶（ALK）阳性ALCL是一种sALCL，通常累及淋巴结和淋巴结部位。皮肤受累通常表现为肿瘤、结节和溃疡。我们描述了一个不寻常的情况下，ALK阳性ALCL在一个11岁的中国男孩，谁最初表现为皮疹与快速进展和预后不良。该病例强调了临床因素对预测ALK阳性sALCL预后的价值，我们建议皮肤科医生、病理科医生和血液科医生/肿瘤科医生密切合作，以确保正确的诊断和治疗。
Systemic anaplastic large cell lymphomas (sALCLs) comprise a heterogeneous group of relatively rare T-cell non-Hodgkin lymphomas that are characterized by CD30 expression. Anaplastic lymphoma kinase (ALK)-positive ALCL is a type of sALCL that commonly involves lymph nodes and extranodal sites. Skin involvement usually presents as tumours, nodules and ulcers. We describe an unusual case of ALK-positive ALCL in an 11-year-old Chinese boy, who initially presented with skin eruption with rapid progression and poor prognosis. This case emphasizes the value of clinical factors to predict the prognosis of ALK-positive sALCL, and we recommend close collaboration between dermatologists, pathologists and haematologists/oncologists to assure the correct diagnosis and treatment.