Anthropometric measures, physical activity, and risk of glioma and meningioma in a large prospective cohort study.
Anthropometric measures, physical activity, and risk of glioma and meningioma in a large prospective cohort study.
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DOI：
10.1158/1940-6207.capr-11-0014
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Riboli E
中科院分区：
文献类型：
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作者：
Michaud DS;Bové G;Gallo V;Schlehofer B;Tjønneland A;Olsen A;Overvad K;Dahm CC;Teucher B;Boeing H;Steffen A;Trichopoulou A;Bamia C;Kyrozis A;Sacerdote C;Agnoli C;Palli D;Tumino R;Mattiello A;Bueno-de-Mesquita HB;Peeters PH;May AM;Barricarte A;Chirlaque MD;Dorronsoro M;José Sánchez M;Rodríguez L;Duell EJ;Hallmans G;Melin BS;Manjer J;Borgquist S;Khaw KT;Wareham N;Allen NE;Travis RC;Romieu I;Vineis P;Riboli E
身体肥胖与许多依赖脂肪的癌症的风险增加有关。最近的研究表明，体重指数可能与脑膜瘤有关，脑膜瘤在女性中比男性更常见，雌激素被认为在其中发挥作用。使用来自一个大型欧洲前瞻性队列的数据，203例脑膜瘤和340例胶质瘤病例被纳入380，775名参与者的体脂，身高和体力活动指标分析。所有分析均采用考克斯比例风险模型进行，并控制年龄、性别、国家和教育程度。在腰围最高四分位数的男性和女性中观察到脑膜瘤风险增加71%（HR = 1.71，95% CI = 1.08-2.73，p趋势=0.01）。还观察到体重指数与脑膜瘤呈正相关（HR = 1.48，95% CI = 0.98-2.23，BMI ≥30与BMI 20-24.9相比，p趋势=0.05）。也提示与身高和脑膜瘤相关（HR = 1.24，95% 0.96-1.51，每增加10 cm）。相比之下，没有观察到身高和不同的体脂测量值与胶质瘤风险之间的关联。体力活动与任何一种类型的脑肿瘤都没有关系。这项研究的结果支持男性和女性中身体肥胖的脑膜瘤风险增加。人体测量指标与神经胶质瘤风险之间没有相关性。
Body fatness has been associated with increased risk of a number of hormone-dependent cancers. Recent studies suggest that body mass index may be related to meningiomas, which are more common in women than men, and for which estrogens are believed to play a role. Using data from a large European propective cohort, 203 incident cases of meningioma and 340 cases of glioma were included in the analysis for measures of body fat, height, and physical activity among 380,775 participants. All analyses were conducted using Cox proportional hazards model and controlling for age, sex, country and education. A 71% increase in risk of meningioma was observed among men and women in the top quartile of waist circumference (HR = 1.71, 95% CI = 1.08–2.73, p-trend=0.01). A positive association was also observed for body mass index and meningioma (HR = 1.48, 95% CI = 0.98–2.23, for BMI ≥30 compared with a BMI of 20–24.9, p trend=0.05). An association with height and meningioma was also suggestive (HR = 1.24, 95% 0.96–1.51, for each 10cm increase). In contrast, no associations were observed for height and different measures of body fat and risk of glioma. Physical activity was not related to either type of brain tumors. Results from this study support an increase in risk of meningioma with higher body fatness among both men and women. No association was observed between anthropometric measures and risk of glioma.