STEROIDOGENESIS IN PREOVULATORY FOLLICLES OF PATIENTS GIVEN HUMAN MENOPAUSAL AND CHORIONIC GONADOTROPHINS AS JUDGED BY THE RADIOIMMUNOASSAY OF STEROIDS IN FOLLICULAR FLUID
STEROIDOGENESIS IN PREOVULATORY FOLLICLES OF PATIENTS GIVEN HUMAN MENOPAUSAL AND CHORIONIC GONADOTROPHINS AS JUDGED BY THE RADIOIMMUNOASSAY OF STEROIDS IN FOLLICULAR FLUID
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通过卵泡液中类固醇的放射免疫分析判断给予人类绝经期和绒毛膜促性腺激素的患者排卵前卵泡中的类固醇生成
DOI：
10.1677/joe.0.0770161
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发表时间：
1978
影响因子：
4
通讯作者：
P. Steptoe
中科院分区：
文献类型：
--
作者：
R. Fowler;R. Edwards;D. E. Walters;S. Chan;P. Steptoe
：在接受不孕症治疗的患者中，先注射人绝经期促性腺激素（HMG），然后注射人绒毛膜促性腺激素（HCG），刺激了不同数量卵泡的发育。注射 HCG 后 32-33 小时，吸出这些患者的 Graafian 卵泡，并通过放射免疫测定法测量卵泡液和匹配血清样本中的类固醇水平。卵泡不能像在月经周期期间接受 HCG 的患者那样分为两个不同的簇，但从树状图中可以将卵泡大致分为四组。其中两组与之前发现的排卵组和非排卵组相似，而另外两组卵泡性质更为中间。判别分析表明，这两组人明显受到了 HMG 和 HCG 的刺激，尽管他们还没有完全排卵。我们的数据表明，通过 HMG 和 HCG 治疗，发育中的卵泡数量显着增加，但卵泡发育存在异步，因为许多卵泡中类固醇合成的模式不同。讨论了这种异步发育对卵母细胞成熟和黄体期紊乱的影响。
: The administration of human menopausal gonadotrophin (HMG) followed by human chorionic gonadotrophin (HCG) stimulated the development of various numbers of follicles in patients treated for infertility. Graafian follicles from these patients were aspirated 32-33 h after the injection of HCG and the levels of steroids in the follicular fluid and matching serum samples were measured by radioimmunoassay. The follicles could not be grouped into two distinct clusters as found in patients given HCG during the menstrual cycle but a broad classification of follicles into four groups was indicated from the dendrogram. Two of the groups were similar to the ovulatory and non-ovulatory groups found previously, whereas the other two groups of follicles were more intermediate in nature. The use of a discriminant analysis showed that these two groups had clearly been stimulated by the HMG and HCG, although they were not yet fully ovulatory. Our data indicate that the number of developing follicles is considerably increased by treatment with HMG and HCG but there is asynchrony in follicular development because the pattern of steroid synthesis differs in many follicles. The effects of this asynchronous development on oocyte maturation and disorders of the luteal phase are discussed.