Solution-phase mixture synthesis with double-separation tagging: Double demixing of a single mixture provides a stereoisomer library of 16 individual murisolins
Solution-phase mixture synthesis with double-separation tagging: Double demixing of a single mixture provides a stereoisomer library of 16 individual murisolins
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DOI：
10.1002/anie.200501989
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发表时间：
2005-01-01
影响因子：
16.6
通讯作者：
Curran, DP
中科院分区：
文献类型：
--
作者：
Wilcox, CS;Gudipati, V;Curran, DP
两个标记物比一个标记物更好：在双重分离标记法的帮助下，一起合成并以纯形式分离出16个Mursolin的单独立体异构体(见方案)。利用氟烷基和低聚乙二醇(OEG，(OCH2CH2)nOCH3)标记实现了一种基于双重分离标记和双重分离的溶液相立体异构体合成策略。
Two tags are better than one: Sixteen individual stereoisomers of murisolin (see scheme) are synthesized together and isolated in pure form with the aid of a double‐separation tagging procedure. A strategy for solution‐phase stereoisomer synthesis based on double‐separation tagging and double demixing is implemented with fluoroalkyl and oligoethylene glycol (OEG, (OCH2CH2)nOCH3) tags.