Flow chemistryMicroreaction technology comes of age
Flow chemistryMicroreaction technology comes of age
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DOI：
10.1002/aic.15642
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发表时间：
2017-03-01
期刊：
影响因子：
3.7
通讯作者：
Jensen, Klavs F.
中科院分区：
文献类型：
--
作者：
Jensen, Klavs F.
在过去的二十年中，微反应技术已经从早期的设备和概念成熟到涵盖广泛的商业设备和应用。微反应器的发展和有机化学中连续流技术的采用共同促进了这一演变。本展望总结了当前最先进的技术，重点是使能技术的反应和分离设备。自动化和优化是微反应器技术的重要应用领域。医药制造业向连续加工的转变，突显了工业对该技术日益增长的兴趣。作为一个例子，在一个紧凑的可重构系统中端到端制造药物说明了基于微反应器的按需制造单元的发展。最后一节提供了该技术的展望，包括实现挑战和与计算工具的集成。化学工程学报，2017 (c) 2016化学工程学报，63:858-869,2017
Over the past two decades, microreaction technology has matured from early devices and concepts to encompass a wide range of commercial equipment and applications. This evolution has been aided by the confluence of microreactor development and adoption of continuous flow technology in organic chemistry. This Perspective summarizes the current state-of-the art with focus on enabling technologies for reaction and separation equipment. Automation and optimization are highlighted as promising applications of microreactor technology. The move towards continuous processing in pharmaceutical manufacturing underscores increasing industrial interest in the technology. As an example, end-to-end fabrication of pharmaceuticals in a compact reconfigurable system illustrates the development of on-demand manufacturing units based on microreactors. The final section provides an outlook for the technology, including implementation challenges and integration with computational tools. AIChE J, 2017 (c) 2016 American Institute of Chemical Engineers AIChE J, 63: 858-869, 2017