ACUTE HEROIN ABSTINENCE IN MAN .3. EFFECT UPON WAKING AND SLOW-WAVE SLEEP
ACUTE HEROIN ABSTINENCE IN MAN .3. EFFECT UPON WAKING AND SLOW-WAVE SLEEP
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DOI：
10.1016/0376-8716(80)90329-4
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发表时间：
1980-01-01
影响因子：
4.2
通讯作者：
HEGGE, FW
中科院分区：
文献类型：
--
作者：
HOWE, RC;PHILLIPS, JL;HEGGE, FW
The effects of acute heroin withdrawal on waking behavior and slow wave sleep were studied. Data were collected from drug-dependent patients who were using pure heroin and from drug-free controls. All data were recorded on a 24 h per day basis for 5-7 consecutive days. EEG records were manually scored according to standard criteria. The heroin-dependent patients during withdrawal showed approximately a 26% decrease in slow wave sleep and an 18% increase in waking behavior. The awake state in the heroin-dependent patients during withdrawal displayed an increase in number of episodes and number of state shifts, and a decrease in duration and sleep onset latency. The slow wave sleep categories during withdrawal generally showed an increase in sleep onset latency and interstate interval and a decrease in number of episodes. Heroin withdrawal is associated with a marked disruption of the CNS mechanisms responsible for maintenance of the normal sleep-waking cycle. Analyses of the pattern of this disruption will further aid in understanding the withdrawal syndrome.
