Risk factors for recurrent tuberculosis after successful treatment in a high burden setting: a cohort study.
Risk factors for recurrent tuberculosis after successful treatment in a high burden setting: a cohort study.
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高负担环境下成功治疗后结核病复发的危险因素：一项队列研究
DOI：
10.1186/s12879-020-05515-4
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发表时间：
2020-10-23
影响因子：
3.7
通讯作者：
Cohen T
中科院分区：
文献类型：
--
作者：
Cudahy PGT;Wilson D;Cohen T
People successfully completing treatment for tuberculosis remain at elevated risk for recurrent disease, either from relapse or reinfection. Identifying risk factors for recurrent tuberculosis may help target post-tuberculosis screening and care. We enrolled 500 patients with smear-positive pulmonary tuberculosis in South Africa and collected baseline data on demographics, clinical presentation and sputum mycobacterial cultures for 24-loci mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing. We used routinely-collected administrative data to identify recurrent episodes of tuberculosis occurring over a median of six years after successful treatment completion. Of 500 patients initially enrolled, 333 (79%) successfully completed treatment for tuberculosis. During the follow-up period 35 patients with successful treatment (11%) experienced a bacteriologically confirmed tuberculosis recurrence. In our Cox proportional hazards model, a 3+ AFB sputum smear grade was significantly associated with recurrent tuberculosis with a hazard ratio of 3.33 (95% CI 1.44–7.7). The presence of polyclonal M. tuberculosis infection at baseline had a hazard ratio for recurrence of 1.96 (95% CI 0.86–4.48). Our results indicate that AFB smear grade is independently associated with tuberculosis recurrence after successful treatment for an initial episode while the association between polyclonal M. tuberculosis infection and increased risk of recurrence appears possible. Supplementary information accompanies this paper at 10.1186/s12879-020-05515-4.
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影响因子：
3.7
作者：
Pascopella L;Deriemer K;Watt JP;Flood JM
通讯作者：
Flood JM
影响因子：
3.8
作者：
Golub, Jonathan E.;Durovni, Betina;Saraceni, Valeria
通讯作者：
Saraceni, Valeria
影响因子：
168.9
作者：
Sonnenberg, P;Murray, J;Godfrey-Faussett, P
通讯作者：
Godfrey-Faussett, P
影响因子：
2.4
作者：
Camlin, Carol S.;Snow, Rachel C.;Hosegood, Victoria
通讯作者：
Hosegood, Victoria
影响因子：
6.4
作者：
Shin, Sanghyuk S.;Modongo, Chawangwa;Zetola, Nicola M.
通讯作者：
Zetola, Nicola M.