Reconstruction of transcription-translation dynamics with a model of gene networks
Reconstruction of transcription-translation dynamics with a model of gene networks
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DOI：
10.1016/j.jtbi.2008.09.006
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发表时间：
2008-12-21
影响因子：
2
通讯作者：
Aihara, K.
中科院分区：
文献类型：
--
作者：
Ichinose, N.;Yada, T.;Aihara, K.
提出了一种基因网络的转录-翻译模型和一种从基因表达数据重构该模型的方法。该模型是一个混合系统的基础上的玻璃网络与连续时间动态和逻辑的相互作用。将转录-翻译动力学引入Glass网络。基因网络的重建被简化为从mRNA和蛋白质的数量的二进制表示估计逻辑函数的问题。将该重建方法应用于昼夜节律的基因表达数据。分析了重构后的基因网络对周期性刺激的响应特性。研究结果表明，存在一种对外部信号做出反应的接收基因，这与生物学知识相一致。(C)2008爱思唯尔有限公司版权所有。
A transcription-translation model of gene networks and a method to reconstruct it from gene expression data are proposed. The model is a hybrid system based on the Glass network with continuous-time dynamics and logical interactions. Transcription-translation dynamics is introduced into the Glass network. The reconstruction of gene networks is reduced to the problem of estimating logical functions from binary representations of quantities of mRNAs and proteins. The reconstruction method is applied to the gene expression data of circadian rhythms. The response characteristics of the reconstructed gene network to periodic stimuli are analyzed. The results suggest the existence of a receiver gene that responds to an external signal, consistently with biological knowledge. (C) 2008 Elsevier Ltd. Ail rights reserved.