Polymeric Nanoparticles for Photodynamic Therapy
Polymeric Nanoparticles for Photodynamic Therapy
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DOI：
10.1007/978-1-61779-052-2_11
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Kopelman, Raoul
中科院分区：
文献类型：
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作者：
Lee, Yong-Eun Koo;Kopelman, Raoul
光动力疗法是一种相对较新的临床治疗方法，它基于三个关键成分：光敏剂、光和分子氧。纳米粒子，特别是靶向纳米粒子，近年来成为药物或造影剂或多种药物的有效载体，与分子药物或造影剂相比具有许多优点，特别是在癌症检测和治疗方面。本文介绍了光动力疗法的研究现状，包括光动力疗法的基本原理、应用和面临的挑战，以及基于纳米颗粒的光动力疗法的最新进展、它们的优点、体外和体内应用的设计和实例，以及它们比现有的基于分子药物的光动力疗法提高光动力疗法疗效的能力。
Photodynamic therapy is a relatively new clinical therapeutic modality that is based on three key components: photosensitizer, light, and molecular oxygen. Nanoparticles, especially targeted ones, have recently emerged as an efficient carrier of drugs or contrast agents, or multiple kinds of them, with many advantages over molecular drugs or contrast agents, especially for cancer detection and treatment. This paper describes the current status of PDT, including basic mechanisms, applications, and challenging issues in the optimization and adoption of PDT; as well as recent developments of nanoparticle-based PDT agents, their advantages, designs and examples of in vitro and in vivo applications, and demonstrations of their capability of enhancing PDT efficacy over existing molecular drug-based PDT.