Scalable fabrication of microneedle arrays via spatially controlled UV exposure
Scalable fabrication of microneedle arrays via spatially controlled UV exposure
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DOI：
10.1038/micronano.2016.49
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发表时间：
2016-10
影响因子：
7.9
通讯作者：
Hidetoshi Takahashi;Yun Jung Heo;Nobuchika Arakawa;Tesuo Kan;Kiyoshi Matsumoto;R. Kawano;I. Shimoyama
中科院分区：
文献类型：
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作者：
Hidetoshi Takahashi;Yun Jung Heo;Nobuchika Arakawa;Tesuo Kan;Kiyoshi Matsumoto;R. Kawano;I. Shimoyama
本文介绍了一种理论估计的几何形状的负环氧树脂抗蚀剂微针通过倾斜/旋转紫外（UV）光刻空间控制的紫外曝光剂量的基础上制备。与其他基于UV光刻的方法相比，本方法可以创建具有高可扩展性的微针结构。当负性光致抗蚀剂通过圆形掩模图案暴露于倾斜/旋转的UV时，在照射区域中形成曝光剂量的三维针状分布。控制倾斜角度和曝光剂量修改光致抗蚀剂的光聚合部分，从而允许通过使用相同的掩模图案形成的微针的高度和轮廓的变化。在一项实验研究中，制造的针的尺寸与不同倾斜角度和暴露剂量的理论预测一致。这些结果表明，我们的理论方法可以提供一个简单的路线，制造微针与按需几何形状。所制造的微针可用作实心微针或用作用于溶解微针的模具母版，从而简化微针制造工艺。我们设想这种方法可以提高制造精度，降低制造成本和时间，从而促进基于微针的药物递送技术的实际应用。
This paper describes a theoretical estimation of the geometry of negative epoxy-resist microneedles prepared via inclined/rotated ultraviolet (UV) lithography based on spatially controlled UV exposure doses. In comparison with other methods based on UV lithography, the present method can create microneedle structures with high scalability. When negative photoresist is exposed to inclined/rotated UV through circular mask patterns, a three-dimensional, needle-shaped distribution of the exposure dose forms in the irradiated region. Controlling the inclination angles and the exposure dose modifies the photo-polymerized portion of the photoresist, thus allowing the variation of the heights and contours of microneedles formed by using the same mask patterns. In an experimental study, the dimensions of the fabricated needles agreed well with the theoretical predictions for varying inclination angles and exposure doses. These results demonstrate that our theoretical approach can provide a simple route for fabricating microneedles with on-demand geometry. The fabricated microneedles can be used as solid microneedles or as a mold master for dissolving microneedles, thus simplifying the microneedle fabrication process. We envision that this method can improve fabrication accuracy and reduce fabrication cost and time, thereby facilitating the practical applications of microneedle-based drug delivery technology.