Invertebrate host responses to microsporidia infections
Invertebrate host responses to microsporidia infections
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无脊椎动物宿主对微孢子虫感染的反应
DOI：
10.1016/j.dci.2018.02.004
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发表时间：
2018-06-01
影响因子：
2.9
通讯作者：
Zhou, Zeyang
中科院分区：
文献类型：
--
作者：
Pan, Guoqing;Bao, Jialing;Zhou, Zeyang
微孢子虫是一组真菌样的细胞内和单细胞寄生虫，几乎可以感染所有动物。作为“主寄生虫”，迄今为止已经描述了超过1400种微孢子虫。经济无脊椎动物中的微孢子虫感染（例如，蚕、虾）造成巨大的经济损失，而水蚤、线虫、蝗虫、蜜蜂和蚊子中的其他微孢子虫感染在调节其种群规模方面发挥重要作用。研究微孢子虫感染后无脊椎动物宿主的反应已经产生了许多有趣的结果，特别是关于这些病原体的先天免疫反应。本文就无脊椎动物对各种微孢子虫感染的反应进行了综述。我们讨论了宿主反应中的许多关键事件，包括泛素介导的抗性，活性氧的产生，黑化和先天免疫途径，以及受感染宿主中基础代谢和保幼激素积累的增加。最近的研究进展，我们的理解微孢子虫感染也突出显示。这些进展为无脊椎动物宿主免疫反应的一般规律和微孢子虫的致病机制提供了新的认识，同时也为进一步研究宿主与胞内病原体之间的相互作用提供了有价值的线索。(C)2018爱思唯尔有限公司版权所有
Microsporidia are a group of fungi-like intracellular and unicellular parasites, which infect nearly all animals. As "master parasites", over 1400 microsporidian species have been described to date. Microsporidia infections in economical invertebrates (e.g., silkworm, shrimp) cause huge financial losses, while other microsporidia infections in daphnia, nematode, locust, honeybee and mosquito play important roles in the regulation of their population size. Research investigating invertebrate host responses following microsporidia infections has yielded numerous interesting results, especially pertaining to the innate immune response to these pathogens. In this review, we comparatively summarize the invertebrate host responses to various microsporidia infections. We discuss numerous critical events in host responses including ubiquitin-mediated resistance, production of reactive oxygen species, melanization and innate immune pathways, and the increased basic metabolism and the accumulation of juvenile hormone in infected hosts. Recent studies progressing our understanding of microsporidia infection are also highlighted. Collectively, these advances shed more light on general rules of invertebrate host immune responses and pathogenesis mechanisms of microsporidia, and concurrently offer valuable clues for further research on the crosstalk between hosts and intracellular pathogens. (C) 2018 Elsevier Ltd. All rights reserved.