Vascular wall elasticity measurement by magnetic resonance imaging
Vascular wall elasticity measurement by magnetic resonance imaging
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DOI：
10.1002/mrm.20991
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发表时间：
2006-09-01
影响因子：
3.3
通讯作者：
Ehman, R. L.
中科院分区：
文献类型：
--
作者：
Woodrum, D. A.;Romano, A. J.;Ehman, R. L.
本研究的目的是确定基于MRI的弹性成像（MRE）方法是否可以可视化和评估充满液体的血管内传播的机械波，并研究通过使用MRE测量血管壁弹性特性和定量评估狭窄病变的可行性。使用薄壁乳胶血管模型测试测量杨氏模量-壁厚乘积的能力。在血管模型中还测试了通过测量透射和反射的机械波来量化狭窄程度的能力。然后将该方法应用于离体猪模型和体内人动脉，以进一步测试其可行性。本研究结果为磁共振成像定量评价血管硬度提供了初步证据，并为测量狭窄程度提供了一种非形态学方法。随着进一步的发展，该方法有可能在体内实施。
The goal of this current study was to determine whether an MRI-based elastography (MRE) method can visualize and assess propagating mechanical waves within fluid-filled vessels and to investigate the feasibility of measuring the elastic properties of vessel walls and quantitatively assessing stenotic lesions by using MRE. The ability to measure the Young's modulus-wall thickness product was tested using a thin-walled latex vessel model. Also tested in vessel models was the ability to quantitate the degree of stenosis by measuring transmitted and reflected mechanical waves. This method was then applied to ex vivo porcine models and in vivo human arteries to further test its feasibility. The results provide preliminary evidence that MRE can be used to quantitatively assess the stiffness of blood vessels, and provide a non-morphologic method to measure stenosis. With further development, it is possible that the method can be implemented in vivo.