Relationship Between Respiratory Sensory Perception, Speech, and Swallow in Parkinson's Disease
Relationship Between Respiratory Sensory Perception, Speech, and Swallow in Parkinson's Disease
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DOI：
10.1002/mdc3.12732
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发表时间：
2019-03-01
影响因子：
4
通讯作者：
Brandimore, Alexandra
中科院分区：
文献类型：
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作者：
Hegland, Karen W.;Troche, Michelle;Brandimore, Alexandra
背景 有人提出，感觉障碍对帕金森病中感觉运动整合受损继发的运动缺陷有显着影响。帕金森病患者的言语和吞咽可能会出现障碍，并且有证据表明上呼吸道感觉受损也会导致这些障碍。目的 本研究的目的是调查帕金森病患者一般呼吸感觉、言语和吞咽感觉之间的关系。方法 13 名 PD 患者和 14 名年龄相当的对照者自愿参加。提供了随机的吸气阻力负荷块，参与者使用修改后的博格量表来测量负荷的大小。然后使用多元方差分析和逐步线性回归模型将幅度估计值与言语和吞咽评估的结果进行比较。结果 参与者组（PD 与对照组）和呼吸负荷之间存在显着的总体交互作用（F [10, 300] = 2.138；P = .022）。发现了包含预测语音变量呼吸评级的显着回归方程（F [1,22] = 6.946），P = .023），中等效应大小为 R-2 = .387。结论 与同龄健康成年人相比，帕金森病患者对呼吸阻力负荷的感知较弱。结果还表明，阻性负载的 ME 减弱可能会导致语音呼吸驱动（即响度）的变化。
Background It has been suggested that sensory impairments contribute significantly to the motor deficits secondary to impaired sensorimotor integration in Parkinson's disease. Speech and swallowing are likely to become disordered in PD, and there is evidence that impaired upper airway sensation also contributes to these disorders. Objectives The goal of this study was to investigate the relationship between perception of general respiratory sensation, speech, and swallowing in PD. Methods Thirteen people with PD and 14 age-equivalent controls volunteered to participate. Randomized blocks of inspiratory resistive loads were delivered, and participants gauged the magnitude of the loads using a modified Borg scale. The magnitude estimates were then compared to results of speech and swallowing evaluations using multivariate analysis of variance and a stepwise linear regression model. Results There was a significant overall interaction between the participant group (PD versus control) and respiratory load (F [10, 300] = 2.138; P = .022). A significant regression equation containing a predictor speech variable respiratory rating was found (F [1,22] = 6.946), P = .023), with a moderate effect size of R-2 = .387. Conclusions People with PD have blunted perception of respiratory resistive loads when compared with age-equivalent healthy adults. Results also suggest that blunted ME of resistive loads could contribute to changes in respiratory drive for speech (i.e., loudness).