PROLACTIN STIMULATION OF MATERNAL-BEHAVIOR IN FEMALE RATS
PROLACTIN STIMULATION OF MATERNAL-BEHAVIOR IN FEMALE RATS
复制标题
DOI：
10.1126/science.3969568
复制
发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
DOHERTY, PC
中科院分区：
文献类型：
--
作者：
BRIDGES, RS;DIBIASE, R;DOHERTY, PC
在实验中使用了用类固醇[雌二醇、孕酮]处理的无经验的切除垂体的雌性大鼠，以研究垂体和催乳素在母性行为表达中的作用。给药绵羊催乳素或异位垂体移植物治疗，将催乳素释放到循环中，刺激了这些雌性大鼠对幼鼠的母性护理。类固醇单独治疗，虽然刺激母体行为的大鼠与完整的垂体，并没有促进母体反应垂体切除的女性。垂体催乳素在建立产妇护理中的刺激行为作用被指出。在分娩期间暴露于催乳素显然有助于刺激分娩时母性行为的立即发生。[催乳素被认为通过中枢神经系统反馈发挥其行为效应。]
Inexperienced, hypophysectomized female rats treated with steroids [estradiol, progesterone] were used in experiments to investigate the roles of the pituitary gland and prolactin in the expression of maternal behavior. Administration of ovine prolactin or treatment with ectopic pituitary grafts, which release prolactin into the circulation, stimulated maternal care in these females toward rat young. Steroid treatment alone, while stimulating maternal behavior in rats with intact pituitary glands, did not facilitate maternal responsiveness in hypophysectomized females. A stimulatory behavioral role for pituitary prolactin in the establishment of maternal care was indicated. Exposure to prolactin during pregnacy evidently helps to stimulate the immediate onset of maternal behavior at parturition. [Prolactin is thought to exert it''s behavioral effects via CNS feedback.].