Surface Laplacians (SL) and phase properties of EEG rhythms: Simulated generators in a volume-conduction model.
Surface Laplacians (SL) and phase properties of EEG rhythms: Simulated generators in a volume-conduction model.
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DOI：
10.1016/j.ijpsycho.2015.05.008
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Kayser J
中科院分区：
文献类型：
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作者：
Tenke CE;Kayser J
表面拉普拉斯（SL）方法提供了频谱分析的优势，由于众所周知的体积传导的影响。虽然SL优于依赖参考的措施的认识是广泛的，合理的警告，排除了他们的普遍采用。值得注意的是，预期的选择性SL的表面，而不是深发电机已降级SL的作用的附加到传统的分析，而不是作为一个独立的调查领域，尽管实证研究结果支持的一致性和可复制性的生理影响的利益。也有理由认为，SL的对比度增强效应必然使其对广泛分布的发生器不敏感，包括那些被怀疑用于振荡节律的发生器，如EEG α。对于阶段敏感的措施，这些担忧进一步加剧（例如，锁相、相干性），其中生理发生器的关键特征还有待评估。虽然由于逆问题而无法精确地知道神经元导出的EEG测量的神经元发生器，但可以使用4球头部模型来模拟简单的偶极子发生器配置并线性组合。我们模拟硬膜下和深层发电机和分布式偶极子层使用正弦和余弦波形，量化在67头皮网站对应于以前的研究中使用的。参考依赖性（鼻子，平均，乳突参考）EEG和相应的SL地形图被用来探测信号保真度的地形测量的振幅谱，相位和相干性的正弦刺激在和之间的“活动”记录网站。SL始终优于传统的EEG测量，表明研究界的持续不情愿是没有根据的。
Surface Laplacian (SL) methods offer advantages in spectral analysis owing to the well-known implications of volume conduction. Although recognition of the superiority of SL over reference-dependent measures is widespread, well-reasoned cautions have precluded their universal adoption. Notably, the expected selectivity of SL for superficial rather than deep generators has relegated SL to the role of an add-on to conventional analyses, rather than as an independent area of inquiry, despite empirical findings supporting the consistency and replicability of physiological effects of interest. It has also been reasoned that the contrast-enhancing effects of SL necessarily make it insensitive to broadly distributed generators, including those suspected for oscillatory rhythms such as EEG alpha. These concerns are further exacerbated for phase-sensitive measures (e.g., phase-locking, coherence), where key features of physiological generators have yet to be evaluated. While the neuronal generators of empirically-derived EEG measures cannot be precisely known due to the inverse problem, simple dipole generator configurations can be simulated using a 4-sphere head model and linearly combined. We simulated subdural and deep generators and distributed dipole layers using sine and cosine waveforms, quantified at 67-scalp sites corresponding to those used in previous research. Reference-dependent (nose, average, mastoids reference) EEG and corresponding SL topographies were used to probe signal fidelity in the topography of the measured amplitude spectra, phase and coherence of sinusoidal stimuli at and between “active” recording sites. SL consistently outperformed the conventional EEG measures, indicating that continued reluctance by the research community is unfounded.