EVALUATION OF A RAPID BEDSIDE ASSAY FOR DETECTION OF SERUM CARDIAC TROPONIN-T
EVALUATION OF A RAPID BEDSIDE ASSAY FOR DETECTION OF SERUM CARDIAC TROPONIN-T
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DOI：
10.1001/jama.273.16.1279
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发表时间：
1995-04-26
影响因子：
120.7
通讯作者：
SACKS, DB
中科院分区：
文献类型：
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作者：
ANTMAN, EM;GRUDZIEN, C;SACKS, DB
目的.-使用含有单克隆抗体的手持设备评估心脏特异性肌钙蛋白 T (cTnT) 的快速、定性床边免疫测定。设计.-快速 cTnT 测定与诊断心肌梗死 (MI) 的临床标准的比较。设置.-三级保健大学医疗中心。患者。-入院评估的 100 名患者队列 胸痛患者就诊时有足够的血样用于测量肌酸激酶、肌酸激酶 MB 分数和快速 cTnT 以及足够的临床数据来确定 MI 的诊断。干预。-无；治疗医生对快速 cTnT 结果不知情。主要结果测量。-MI 快速 cTnT 测定的敏感性和特异性；快速 cTnT 检测结果阳性和阴性的似然比；入院时快速 cTnT 检测结果呈阳性的严重心脏事件的相对风险 (RR)。结果。-快速 cTnT 检测的敏感性从胸痛发作后 2 小时内的 33% 增加到 8 小时后的 86%（P
Objective.-To evaluate a rapid, qualitative, bedside immunoassay for cardiac-specific troponin T (cTnT) using a handheld device containing monoclonal antibodies.Design.-Comparison of rapid cTnT assay with clinical standard for diagnosis of myocardial infarction (MI).Setting.-Tertiary care university medical center.Patients.-A cohort of 100 patients admitted for evaluation of chest pain who had sufficient blood samples at presentation for measurement of creatine kinase, creatine kinase MB fraction, and rapid cTnT as well as adequate clinical data to establish the diagnosis of MI.Intervention.-None; treating physicians were blinded to rapid cTnT results.Main Outcome Measures.-Sensitivity and specificity of rapid cTnT assay for MI; likelihood ratios of positive and negative rapid cTnT assay results; relative risk (RR) for serious cardiac events with positive rapid cTnT assay result on admission.Results.-Sensitivity of the rapid cTnT assay increased from 33% within 2 hours from the onset of chest pain to 86% after 8 hours (P