Nicotine metabolite ratio predicts smoking topography: The Pennsylvania Adult Smoking Study
Nicotine metabolite ratio predicts smoking topography: The Pennsylvania Adult Smoking Study
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DOI：
10.1016/j.drugalcdep.2018.06.003
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发表时间：
2018-09-01
影响因子：
4.2
通讯作者：
Muscat, Joshua E.
中科院分区：
文献类型：
--
作者：
Chen, Allshine;Krebs, Nicolle M.;Muscat, Joshua E.
背景：尼古丁代谢物比率（NMR）是由3'羟基可替宁与可替宁的比值测量的，已经研究了与烟草使用模式（包括每天吸烟和戒烟成功）的关系，以确定其在尼古丁依赖中的作用。我们检查了与吸烟地形有关的核磁共振，并测试了正常代谢者比缓慢代谢者有更大的每日总吞吐量的假设。方法：宾夕法尼亚成人吸烟研究（PASS）是一项对352名平均每天吸烟17支的成年人进行的纵向研究。在为期两天的时间里，研究对象在家中和工作场所使用便携式吸烟地形仪。我们测量了受试者唾液中3′羟基可替宁与可替宁的比值。结果：在多元线性回归分析中，较高的尼古丁代谢率与增加的每日吞吐量和总吞吐量显著相关。在一项中介分析中，观察到种族对核磁共振和吞吐体积之间的关系有显著的间接影响，其中22%的影响由白人介导。较高的核磁共振也与女性、白人、每天吸烟和尼古丁依赖程度有关。结论：核磁共振与包括吸烟地形在内的烟草使用模式有关。更快的尼古丁代谢与更大的每日总吞吐量和吞吐量有关。
Background: The nicotine metabolite ratio (NMR) as measured by the ratio of 3'hydroxycotinine to cotinine has been examined in relation to tobacco use patterns including cigarettes per day and quit success to determine its role in nicotine dependence. We examined the NMR in relation to smoking topography and tested the hypothesis that normal metabolizers have a greater total daily puff volume than slow metabolizers.Methods: The Pennsylvania Adult Smoking Study (PASS) is a longitudinal study of 352 adults who smoked, on average, 17 cigarettes per day. Subjects used a portable smoking topography device over a two-day period at home and at work. We measured the ratio of 3'hydroxycotinine to cotinine in the saliva of the subjects.Results: In multiple linear regression analyses, a higher rate of nicotine metabolism was significantly associated with increased daily puffs and total daily puff volume. In a mediation analysis, a significant, indirect effect of race on the relationship between NMR and puff volume was observed, with 22% of the effect mediated by white race. A higher NMR was also associated with female gender, white race, cigarettes per day and nicotine dependence measures.Conclusion: The NMR was associated with tobacco use patterns including smoking topography. Faster nicotine metabolism was associated with greater total daily puffs and puff volume.