Association Between Hyperreflective Foci in the Outer Retina, Status of Photoreceptor Layer, and Visual Acuity in Diabetic Macular Edema
Association Between Hyperreflective Foci in the Outer Retina, Status of Photoreceptor Layer, and Visual Acuity in Diabetic Macular Edema
复制标题
DOI：
10.1016/j.ajo.2011.08.041
复制
发表时间：
2012-04-01
影响因子：
4.2
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Uji, Akihito;Murakami, Tomoaki;Yoshimura, Nagahisa
目的：探讨糖尿病性黄斑水肿（DME）患者外视网膜的高反射灶是否与光感受器完整性和最小分辨角（logMAR）视力（VA）的对数有关。设计：回顾性、观察性、横断面研究。方法：回顾性分析无浆液性视网膜脱离的临床相关性黄斑水肿患者76例（108眼）。所有患者均获得光谱域光学相干断层扫描（SD-OCT）图像。结果：SD-OCT显示视网膜外层高反射灶58只（53.7%）眼，视网膜内层高反射灶107只（99.1%）眼。视网膜外层有高反射灶组的logMAR VA显著低于无高反射灶组（0.463 +/- 0.382 vs 0.127 +/- 0.206）。OCT上ELM线的破坏与视网膜外层的高反射灶和低logMAR VA显著相关（P < 0.0001，两项比较）。内外段线连接处的破坏也与视网膜外层的高反射灶和低logMAR VA相关（P < 0.0001，两项比较）。结论：外视网膜高反射灶的存在与SD-OCT图像上ELM和is /OS线的破坏以及DME中VA的降低密切相关。[J]中华眼科杂志，2012;33(3):391 - 391。(C) 2012年Elsevier Inc.版权所有。)
PURPOSE: To determine if hyperreflective foci in the outer retina are associated with photoreceptor integrity and the logarithm of minimal angle of resolution (logMAR) visual acuity (VA) in patients with diabetic macular edema (DME).DESIGN: Retrospective, observational, cross-sectional study.METHODS: Patients (n = 76; 108 eyes) with clinically relevant macular edema and no serous retinal detachment were analyzed retrospectively. Spectral-domain optical coherence tomography (SD-OCT) images were obtained for all patients. We investigated the relationship between the hyperreflective foci in the outer retinal layers of the external limiting membrane (ELM) at the fovea and the photoreceptor integrity and VA.RESULTS: SD-OCT showed that 58 eyes (53.7%) had hyperreflective foci in the outer retinal layers, and 107 eyes (99.1%) had hyperreflective foci in the inner retinal layers. The logMAR VA was significantly (P < .0001) worse in eyes with hyperreflective foci in the outer retinal layers than in eyes without them (0.463 +/- 0.382 vs 0.127 +/- 0.206, respectively). Disruption of the ELM line on OCT was significantly (P < .0001, for both comparisons) associated with both hyperreflective foci in the outer retinal layers and poor logMAR VA. Disruption of the junction of the inner and outer segment line (IS/OS) also was related to hyperreflective foci in the outer retinal layers and poor logMAR VA (P < .0001 for both comparisons).CONCLUSIONS: The presence of hyperreflective foci in the outer retina is closely associated with a disrupted ELM and IS/OS line on SD-OCT images and decreased VA in DME. (Am J Ophthalmol 2012;153:710-717. (C) 2012 by Elsevier Inc. All rights reserved.)