Tumor Cell Invasion-Not All Barriers Are Created Equal.
Tumor Cell Invasion-Not All Barriers Are Created Equal.
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DOI：
10.1158/0008-5472.can-16-0550
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发表时间：
2016-04-01
期刊：
影响因子：
11.2
通讯作者：
Welch DR
中科院分区：
文献类型：
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作者：
Welch DR
侵袭在复杂的转移过程中的重要性，尽管现在已经得到了很好的证实，但由于体外实验方法的发展，分子细节已经越来越多地被研究。在这一期的癌症研究中，我们重点介绍了George Poste和他的同事发表的一篇论文，该论文比较和对比了几种不同的侵袭分析。作者得出结论，不同的屏障施加了不同的选择压力，简单地增强侵袭能力并不一定会转化为更高的转移效率。尽管这些发现现在可能显而易见，但当它们发表时，却令人惊讶。当然，这些数据强调了肿瘤细胞-微环境相互作用的重要性，以及解释考虑到背景的实验的必要性。
The importance of invasion in the complex process of metastasis, although now well established, has been studied with increasing molecular detail due to the development of robust in vitro experimental assays. In this issue of Cancer Research, we highlight a paper published by George Poste and colleagues that compared and contrasted several different invasion assays. The authors concluded that various barriers impose different selective pressures and that simply enriching for invasive ability didn’t necessarily translate into greater metastasis efficiency. Although perhaps obvious now, these findings were surprising when they were published. Certainly, the data highlight the importance of tumor cell-microenvironment interactions and the necessity to interpret experiments taking the context into consideration.