Recent progress in gene delivery using non-viral transfer complexes
Recent progress in gene delivery using non-viral transfer complexes
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DOI：
10.1016/s0168-3659(01)00267-x
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发表时间：
2001-05-14
影响因子：
10.8
通讯作者：
Mikos, AG
中科院分区：
文献类型：
--
作者：
Godbey, WT;Mikos, AG
将遗传物质输送到细胞中是一个发展非常迅速的领域。非病毒递送方法，特别是那些专注于使用与遗传物质复合的化学制剂的方法，是这次小型审查的重点。最近使用已知的转染剂，如聚（乙烯亚胺），聚（L-赖氨酸），和各种脂质体进行了讨论，和一些新的方法（包括化学和方法）进行审查。一个非常简短的看看如何非病毒基因传递研究正在针对临床也包括在内。(C)2001 Elsevier Science B. V.保留所有权利。
The delivery of genetic material into cells is a field that is expanding very rapidly. Non-viral delivery methods, especially ones that focus on the use of chemical agents complexed with genetic material, are the focus of this mini-review. More-recent uses of known transfection agents such as poly(ethylenimine), poly(L-lysine), and various liposomes are discussed, and some novel approaches (both chemical and methodical) are reviewed as well. A very brief look at how non-viral gene delivery research is being aimed at the clinic is also included. (C) 2001 Elsevier Science B.V. All rights reserved.