Ultrasmall Phosphorescent Polymer Dots for Ratiometric Oxygen Sensing and Photodynamic Cancer Therapy
Ultrasmall Phosphorescent Polymer Dots for Ratiometric Oxygen Sensing and Photodynamic Cancer Therapy
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用于比例氧传感和光动力癌症治疗的超小磷光聚合物点
DOI：
10.1002/adfm.201400647
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发表时间：
2014-08-13
影响因子：
19
通讯作者：
Huang, Wei
中科院分区：
文献类型：
--
作者：
Shi, Huifang;Ma, Xing;Huang, Wei
设计、合成了一系列由磷光Ir(III)配合物和主链上的聚荧烯单元组成的半导体聚合物点(Pdots)，并将其应用于比率式氧传感和光动力学癌症治疗。由于聚合物的两亲性，在水溶液中制备了粒径小于10 nm的超小Pdots。Pdots具有良好的光稳定性、生物相容性和从聚合物主链到Ir(III)络合物的有效能量转移。利用激发态能量从磷光Pdots向基态分子氧的转移，这些Pdots被应用于氧的光学传感，具有比例式和肉眼检测以及在水溶液中的高灵敏度。Pdots还表现出低的细胞毒性，可以穿过细胞膜进入细胞质。Pdots在488 nm光照射下产生的单线态氧可以有效地诱导肿瘤细胞的凋亡和死亡，用于体外光动力学肿瘤治疗。
A series of semiconducting polymer dots (Pdots) composed of phosphorescent Ir(III) complexes and polyfluorene units in the main polymer chains are designed, synthesized, and applied in ratiometric oxygen sensing and photodynamic cancer therapy. The ultrasmall Pdots with particle size less than 10 nm are fabricated in aqueous solution on account of amphiphilic nature of the polymers. The Pdots possess fine photostability, biocompatibility, and efficient energy transfer from the polymer main chain to the Ir(III) complex. By utilizing the excited‐state energy transfer from phosphorescent Pdots to the ground state molecular oxygen, these Pdots are applied in the optical sensing of oxygen with ratiometric and naked‐eye detection as well as high sensitivity in aqueous solution. The Pdots also show low cytotoxicity and can pass across the cell membrane to enter into the cytoplasm. The singlet oxygen photo‐generated from the Pdots under irradiation at 488 nm can effectively induce the apoptosis and death of tumor cells for photodynamic cancer therapy in vitro.