Testing between-family associations in within-family comparisons
Testing between-family associations in within-family comparisons
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DOI：
10.1111/1467-9280.00279
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发表时间：
2000-09-01
影响因子：
8.2
通讯作者：
Rose, RJ
中科院分区：
文献类型：
--
作者：
Dick, DM;Johnson, JK;Rose, RJ
使用行为不一致的兄弟姐妹来测试基因-行为关联是分子遗传学中的一种常用工具，因为家族内对比提供了一种研究设计，避免了在所有无关个体的家族间比较中不可避免的混淆。我们提出了一个类似的策略，以评估行为的行为协会上，许多心理科学的基础。性格测试分数的家庭间相关性（例如，感觉寻求）和行为结果（例如，物质使用）可以由不同家庭之间的变量介导（例如，社会阶层或宗教信仰），并与人格和结果相关。对比双胞胎和非双胞胎兄弟姐妹谁是高度不一致的行为相关的物质使用，我们测试是否家庭间的行为相关性复制家庭内。有些人，但不是全部，做了。行为不和谐的兄弟姐妹的家庭内分析可能会发现广泛的应用，努力澄清相关研究数据的意义。
Using behaviourally discordant siblings to test for gene-behavior associations is a common tool in molecular genetics, because the within-family contrast offers a research design that avoids confounds inevitable in all between-family comparisons of unrelated individuals. We propose a similar strategy to assess the behaviour-behaviour associations on which much of psychological science is built. Between-family correlations of personality test scores (e.g., sensation seeking) and behavioural outcomes (e.g., substance use) may be mediated by variables that differ between families (e.g., social class or religiosity) and correlate with both personality and outcome. Contrasting twin and nontwin siblings who were highly discordant for behavioral correlates of substance use, we tested whether between-family behavioral correlations replicated within families. Some, but not all, did. Within-family analysis of behaviorally discordant siblings may find wide application in efforts to clarify the meaning of correlational research data.