Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York.
Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York.
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DOI：
10.7916/d8k35sd4
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发表时间：
2000-11
期刊：
影响因子：
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通讯作者：
S. Stellman;M. Djordjevic;J. Britton;J. Muscat;M. Citron;M. Kemeny;E. Busch;L. Gong
中科院分区：
文献类型：
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作者：
S. Stellman;M. Djordjevic;J. Britton;J. Muscat;M. Citron;M. Kemeny;E. Busch;L. Gong
为了评估有机氯化合物在纽约州长岛乳腺癌发病中可能的病因作用，测量了232名乳腺癌患者和323名因良性乳腺疾病或非乳腺相关疾病接受手术的医院对照组脂肪组织中有机氯农药和多氯联苯（PCBs）的浓度。通过超临界流体萃取法，然后用气相色谱电子捕获检测器测定了7种农药残留和14种多氯联苯同系物。调整后的年龄和体重指数，这是密切相关的有机氯水平，脂肪浓度的1，1-二氯-2，2-二（4-氯苯基）乙烯，总农药，总多氯联苯（PCBs）没有显着差异病例和对照组之间。在病例和对照中，个别农药种类和多氯联苯同系物的相对丰度相似。根据年龄、体重指数、医院和种族调整的比值比没有证据表明1，1-二氯-2，2-二（4-氯苯基）乙烯、总农药或总多氯联苯的剂量反应，无论是否按雌激素受体状态分层。与邻近的纽约市皇后区的居民相比，长岛居民患乳腺癌的风险并没有升高。我们没有证实先前报告的乳腺癌风险与PCB同系物118（2，3 '，4，4'，5-五氯联苯）水平之间的关联，也没有观察到与最丰富的同系物153（2，2 '，4，4'，5，5 '-六氯联苯）之间的关联，这是一种强诱导剂，最近报告称具有雌激素特性。只有多氯联苯同系物183（2，2 '，3，4，4'，5 '，6-七氯联苯）（也是一种诱导剂）与风险显著相关，在脂肪含量>5.67纳克/克的妇女中，调整后的比值比为2.0（95%置信区间，1.2-3.4）;这一观察结果的生物重要性尚不清楚，没有进一步的研究证实。尽管目前的研究和其他研究都没有提供令人信服的证据，证明人体内1，1，1-三氯-2，2-双（4-氯苯基）乙烷和多氯联苯的含量与乳腺癌之间存在关联，但国际癌症研究机构将这些化合物分别列为“可能”和“可能”的人类致癌物。应进行与其他部位癌症相关性的调查。
To assess a possible etiological role of organochlorine compounds in breast cancer development on Long Island, a high-risk region of New York State, concentrations of organochlorine pesticides and polychlorinated biphenyls (PCBs) were measured in the adipose tissue of 232 women with breast cancer and 323 hospital controls admitted to surgery for benign breast disease or non-breast-related conditions. Seven pesticide residues and 14 PCB congeners were assayed via a supercritical fluid extraction method followed by gas chromatography with electron capture detection. After adjustment for age and body mass index, which were strongly correlated with organochlorine levels, adipose concentrations of 1,1-dichloro-2,2-di(4-chlorophenyl)ethylene, total pesticides, and total polychlorinated biphenyls (PCBs) did not differ significantly between cases and controls. The relative abundance of individual pesticide species and PCB congeners was similar in cases and controls. Odds ratios adjusted for age, BMI, hospital, and race gave no evidence of a dose-response for 1,1-dichloro-2,2-di(4-chlorophenyl)ethylene, total pesticides, or total PCBs, whether stratified by estrogen receptor status or not. Breast cancer risk among Long Island residents was not elevated compared with residents of the adjacent New York City borough of Queens. We did not confirm a previously reported association between breast cancer risk and levels of PCB congener 118 (2,3',4,4',5-pentachlorobiphenyl), nor did we observe an association with the most abundant congener 153 (2,2',4,4',5,5'-hexachlorobiphenyl), a strong inducer of phase I enzymes that was reported recently to have estrogenic properties. Only PCB congener 183 (2,2',3,4,4',5',6-heptachlorobiphenyl), which is also an inducer, was significantly associated with risk, with an adjusted odds ratio of 2.0 (95% confidence interval, 1.2-3.4) in women with adipose levels >5.67 ng/g; the biological importance of this observation is unclear without confirmation in additional studies. Although neither the present nor other studies have provided convincing evidence of an association between body burden of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane and PCBs with cancer of the breast, these compounds are rated as "possible" and "probable" human carcinogens, respectively, by the International Agency for Research on Cancer. Investigations of associations with cancer at other sites should be carried out.