Memory retrieval and the passage of time: from reconsolidation and strengthening to extinction.
Memory retrieval and the passage of time: from reconsolidation and strengthening to extinction.
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DOI：
10.1523/jneurosci.4736-10.2011
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发表时间：
2011-02-02
期刊：
影响因子：
--
通讯作者：
Alberini CM
中科院分区：
文献类型：
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作者：
Inda MC;Muravieva EV;Alberini CM
一个已经建立的记忆如果被提取或重新激活，可能会变得暂时不稳定。随着时间的推移，它再次变得抵抗破坏，这个使记忆稳定的过程被称为重新巩固。为什么记忆在提取后变得不稳定并重新巩固的原因仍然存在争议。在这里，使用抑制性回避（IA）学习大鼠，我们提供的证据表明，检索的年轻的记忆，这是伴随着其重新巩固，导致记忆增强，并有助于其整体巩固。这种与再固结相关的功能在时间上是有限的。随着时间的推移，存储的记忆经历了重要的变化，正如其检索的行为结果所揭示的那样。随着时间的推移，没有明确的检索，记忆首先加强，并成为检索依赖的干扰和加强。在以后的时间里，同样的检索导致年轻的记忆重新巩固，消除了旧的记忆。我们的结论是，信息的存储是非常动态的，其时间演变调节行为的结果。这些结果对于潜在的临床应用是重要的。
An established memory can be made transiently labile if retrieved or reactivated. Over time, it becomes again resistant to disruption and this process that renders the memory stable is termed reconsolidation. The reasons why a memory becomes labile after retrieval and reconsolidates still remains debated. Here, using inhibitory avoidance (IA) learning in rats, we provide evidence that retrievals of a young memory, which are accompanied by its reconsolidation, result in memory strengthening and contribute to its overall consolidation. This function associated to reconsolidation is temporally limited. With the passage of time, the stored memory undergoes important changes, as revealed by the behavioral outcomes of its retrieval. Over time, without explicit retrievals, memory first strengthens and becomes refractory to both retrieval-dependent interference and strengthening. At later times, the same retrievals that lead to reconsolidation of a young memory extinguish an older memory. We conclude that the storage of information is very dynamic and that its temporal evolution regulates behavioral outcomes. These results are important for potential clinical applications.