Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
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DOI：
10.1182/blood-2011-11-392324
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发表时间：
2012-05-10
期刊：
影响因子：
20.3
通讯作者：
Campbell, Daniel J.
中科院分区：
文献类型：
--
作者：
Duhen, Thomas;Duhen, Rebekka;Campbell, Daniel J.
Foxp3(+)调节性T(Treg)细胞是一种具有广泛作用和强大抗炎功能的CD4(+)T细胞，对维持免疫稳态和防止衰弱的自身免疫至关重要。基于趋化因子受体的表达，我们确定了人类血液中不同的Treg细胞群体，预计它们与不同的Th细胞亚群共存。虽然每个群体都是功能抑制的，但他们表现出独特的促炎和抗炎细胞因子产生模式，差异表达谱系特定的转录因子，并对与Th1和Th17反应相关的抗原做出不同的反应。这些结果突显了人类Treg细胞的表型和功能多样性以前从未被认识到的程度，这使得具有独特特异性和免疫调节功能的亚群在不同类型的炎症反应期间被靶向于特定的免疫环境。(血。2012年；119(19)：4430-4440)
FOXP3(+) regulatory T (Treg) cells are a broadly acting and potent anti-inflammatory population of CD4(+) T cells essential for maintaining immune homeostasis and preventing debilitating autoimmunity. Based on chemokine receptor expression, we identified distinct populations of Treg cells in human blood expected to colocalize with different Th cell subsets. Although each population was functionally suppressive, they displayed unique patterns of pro- and anti-inflammatory cytokine production, differentially expressed lineage-specifying transcription factors, and responded differently to antigens associated with Th1 and Th17 responses. These results highlight a previously unappreciated degree of phenotypic and functional diversity in human Treg cells that allows subsets with unique specificities and immunomodulatory functions to be targeted to defined immune environments during different types of inflammatory responses. (Blood. 2012;119(19):4430-4440)