A third neuroglial cell types. An electron microscopic study
A third neuroglial cell types. An electron microscopic study
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第三种神经胶质细胞类型。
DOI：
10.1002/cne.901330207
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发表时间：
1968
影响因子：
2.5
通讯作者：
A. Peters
中科院分区：
文献类型：
--
作者：
J. Vaughan;A. Peters
在研究视神经发育过程中，有必要重新评估早期的电子显微镜证据，即中央白色物质中仅包含两种神经胶质细胞类型，少突胶质细胞和纤维星形胶质细胞。对成人视神经的重新检查表明，除了这两种细胞外，还存在第三种形态上不同的细胞类型。这第三种神经胶质细胞较小，其胞质密度低于所有形式的少突胶质细胞，但略高于星形胶质细胞。在第三类神经胶质细胞中既没有观察到星形胶质细胞特有的细丝和糖原颗粒，也没有观察到少突胶质细胞特有的微管。细胞质内常出现致密的层状小体和脂肪滴，颗粒内质网的轮廓由长而细的池组成。胎儿和出生后早期的视神经包含一种具有相同形态特征的细胞类型。这表明，成人神经中的第三种神经胶质细胞可能与其他组织的多能干细胞具有相似的性质。第三种神经胶质细胞的一些特征让人想起经典光学显微镜下的小胶质细胞，但发育神经的数据表明，前者来自神经外胚层基质细胞，而不是来自入侵的间充质成分。
During a study of developing optic nerves, it was necessary to reevaluate the earlier electron microscopic evidence that only two neuroglial types, oligodendrocytes and fibrous astrocytes, are contained within central white matter. A reexamination of adult optic nerves showed that in addition to these two kinds of cells, a third morphologically distinct cell type exists. Cells of this third neuroglial variety are small and their cytoplasmic density is less than that of all forms of oligodendrocytes but slightly more than that of astrocytes. Neither the filaments and glycogen particles characteristic of astrocytes nor the microtubules typical of oligodendrocytes are observed in the third type of neuroglia. Dense, laminar bodies and fat droplets are frequently present within their cytoplasm, and profiles of the granular endoplasmic reticulum consist of long, stringy cisternae. Fetal and early postnatal optic nerves contain a cell type with the same morphological characteristics. This suggests that the third type of neuroglia in adult nerves may represent cells of a similar nature to the multipotential stem cells of other tissues. Some of the characteristics of the third type of neuroglia are reminiscent of the microglia of classical light microscopy, but data from developing nerves indicates that the former are derived from neuroectodermal matrix cells and not from invading mesenchymal elements.