Serotyping of Streptococcus pyogenes isolated from common and severe invasive infections in Japan, 1990-5: implication of the T3 serotype strain-expansion in TSLS
Serotyping of Streptococcus pyogenes isolated from common and severe invasive infections in Japan, 1990-5: implication of the T3 serotype strain-expansion in TSLS
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DOI：
10.1017/s0950268897007644
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发表时间：
1997-08-01
影响因子：
4.2
通讯作者：
Watanabe, H
中科院分区：
文献类型：
--
作者：
Inagaki, Y;Konda, T;Watanabe, H
为了阐明日本严重侵袭性A组链球菌感染（链球菌中毒性休克样综合征; TSLS）流行与常见A组链球菌感染之间的关系，我们检测了S.从1990 ~ 1995年17999例链球菌感染的临床标本中分离出化脓性链球菌（A群链球菌），其中包括1992 ~ 1995年29例重症感染（TSLS）。结果表明：（1）T12、T4、T1、T28和TB 3264是这几个时期的优势血清型，且分离株的分布较为一致，（2）T3的分离株在1990 ~ 1994年间迅速增加，而T6的分离株在1990 ~ 1993年间有所下降;（3）当日本地区分为三个部分时，T3血清型有从东北部向西南部扩散的趋势，（4）T3和T1血清型菌株在TSLS中占优势。链球菌感染的优势血清型菌株并不总是引起严重感染，T3血清型在TSLS中的优势似乎与链球菌感染中T3的增加相关。这些结果可能表明，S.化脓菌参与了TSLS的发病机制。
To clarify the relationship between the epidemics of severe invasive group A streptococcal infections (streptococcal Toxic Shock-Like Syndrome; TSLS) and common group A streptococcal infections in Japan, we examined the T serotypes of S. pyogenes strains (group A streptococci) isolated from clinical specimens of the streptococcal infections (17999 cases) in the period 1990-5, including the severe infections (TSLS) (29 cases) in the period 1992-5. Characteristic points of the analyses were: (1) dominant serotypes of the infections in these periods were T12, T4, T1, T28 and TB3264, which were consistently isolated; (2) isolates of T3 rapidly increased through 1990 to 1994 while T6 decreased in the period 1990-3; (3) when Japanese area was divided into three parts, T3 serotype tended to spread out from the northeastern to the south-western area; (4) strains of T3 and T1 serotypes were dominant in the TSLS. Dominant-serotype strains of streptococcal infections did not always induce severe infections and dominance of T3 serotype in the TSLS seemed to be correlated with the increase of T3 in streptococcal infections. These results may indicate that certain clones of S. pyogenes are involved in the pathogenesis of the TSLS.