Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice
Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice
复制标题
喹硫平防止全脑缺血小鼠海马少突胶质细胞和髓鞘质丢失并促进少突胶质细胞祖细胞成熟
DOI：
10.1111/j.1471-4159.2012.07883.x
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发表时间：
2012-10-01
影响因子：
4.7
通讯作者：
Li, Xin-Min
中科院分区：
文献类型：
--
作者：
Bi, Xiaoying;Zhang, Yanbo;Li, Xin-Min
白质损伤是血管抑制的一个特征。抗精神病药物喹硫平已被证明能增强抗抑郁药物对血管性抑郁症的治疗效果，但其机制尚不清楚。在这项研究中，我们发现，在血管抑制动物模型中，在双侧颈动脉闭塞和再灌注前给予奎硫平2周治疗，与安慰剂治疗的小鼠相比，术后天（POD）髓磷脂分解和少突胶质细胞损失减少7。对于恢复晚期（POD40），相对于安慰剂，喹硫平治疗导致少突胶质细胞成熟增强。结果表明，喹硫平可能是对少突胶质细胞损伤的潜在干预，这可能有助于其通过白质保护血管抑郁的抗抑郁作用。
White matter impairment is a feature of vascular depression. The anti-psychotic quetiapine has been shown to enhance the therapeutic effects of anti-depressants on vascular depression, but the mechanism remains unknown. In this study, we found that 2 weeks of treatment with quetiapine prior to bilateral carotid artery occlusion and reperfusion, in an animal model of vascular depression, resulted in reduced myelin breakdown and oligodendrocyte loss compared to placebo-treated mice on post-operative day (POD) 7. For late stage of recovery (POD40), quetiapine treatment resulted in enhanced oligodendrocyte maturation relative to placebo. The results suggest that quetiapine is a potential intervention for oligodendrocyte damage and this may contribute to its anti-depressant effects through white matter protection in vascular depression.