Virus meet metal-organic frameworks: A nanoporous solution to a world-sized problem?
Virus meet metal-organic frameworks: A nanoporous solution to a world-sized problem?
复制标题
DOI：
10.1016/j.mattod.2020.10.024
复制
发表时间：
2021-04-08
期刊：
影响因子：
24.2
通讯作者：
Almeida Paz, Filipe A.
中科院分区：
文献类型：
--
作者：
Figueira, Flavio;Barbosa, Jessica S.;Almeida Paz, Filipe A.
病毒引起的病理学实验室诊断在疫情应对工作和建立安全、快速的检测战略方面发挥着关键作用。使用商业解决方案检测致病性病毒需要特定的工具和费力的实验室程序。这使得每天及时检测病毒感染成为任何疫情爆发的限制步骤。迫切需要向卫生基础设施和训练有素的人员稀缺的贫穷和农村欠发达地区提供易于获得的新诊断工具。金属有机框架（MOFs）的广泛已知的固有特性体现了它们克服病毒检测固有的一些挑战的潜力。MOFs已经是能够进行真实的实时分子靶的不间断检测的功能装置的组件。本文综述了近年来国内外有关MOFs作为致病性病毒传感器的研究进展。我们强调这些材料的结构和物理特性，这可以打开它们在这种类型的传感器中使用的可能性，并总结该领域如何能够发展到设想由制药行业使用MOFs来开发这些亚微观感染因子的新传感器。
Laboratory diagnosis of pathologies caused by virus plays a critical role in outbreak response efforts and establishing safe and expeditious testing strategies. Detection of pathogenic virus using commercial solutions require specific tools and laborious laboratory procedures. This makes the day-to-day on time detection of virus infections the limiting step in any outbreak. The need for new diagnostic tools easily available to poor and rural underdeveloped areas where health infrastructure and trained personnel are scarce is highly desirable. The widely known intrinsic properties of Metal-Organic Frameworks (MOFs) embody them with the potential to overcome some of the challenges inherent to virus detection. MOFs are already components of functional devices capable of perform an uninterrupted detection of molecular targets in real time. In this review, we summarise the few studies concerning the reported MOFs used as sensors for pathogenic virus. We emphasise the structural and physical properties of these materials which can open the possibility for their use in this type of sensors and conclude on how the field can progress to envisage the usage of MOFs by the pharmaceutical industry to develop new sensors for these sub-microscopic infectious agents.