Prevalence and predictors of chronic kidney disease in newly diagnosed human immunodeficiency virus patients in Owerri, Nigeria.
Prevalence and predictors of chronic kidney disease in newly diagnosed human immunodeficiency virus patients in Owerri, Nigeria.
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DOI：
10.4103/0971-4065.156115
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发表时间：
2016-01-01
影响因子：
0.8
通讯作者：
Ulasi, I
中科院分区：
文献类型：
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作者：
Anyabolu, E N;Chukwuonye, I I;Ulasi, I
人类免疫缺陷病毒(HIV)感染是撒哈拉以南非洲慢性肾脏疾病(CKD)的常见原因。这项研究旨在确定尼日利亚东南部奥韦里新诊断的HIV患者中CKD的患病率和预测因素。这是一项横断面研究，包括393名新诊断为HIV血清阳性的受试者和136名年龄和性别匹配的血清阴性受试者作为对照。慢性肾功能不全定义为24小时尿蛋白定量(24-HUP)、≥0.3g和/或肾小球滤过率(GFR)和(或)60ml/min。受试者来自Owerri的HIV诊所和联邦医疗中心的医疗门诊部。收集临床和人体测量数据。进行了相关调查，包括艾滋病毒筛查和相关的尿液和血液调查。HIV感染者的平均年龄为38.84±10.65岁。86例(22.9%)HIV感染者和11例(8.1%)对照组存在CKD。低腰围(WC)、高血肌酐、高尿蛋白/肌酐比值(SUPCR)、高24-HUP/肌酐比值(24-HUPCR)、高24-HUP/渗透压比值(24-HUPOR)是预测CKD的危险因素。在尼日利亚东南部新诊断的艾滋病毒患者中，慢性肾脏病的患病率很高(22.9%)。CKD的预测因素包括WC、血肌酐、SUPCR24-HUPCR24-HUPOR。
Human immunodeficiency virus (HIV) infection is a common cause of chronic kidney disease (CKD) in Sub-Saharan Africa. This study aims at identifying the prevalence and predictors of CKD in newly diagnosed HIV patients in Owerri, South East Nigeria. This was a cross-sectional study consisting of 393 newly diagnosed HIV-seropositive subjects and 136 age- and sex-matched seronegative subjects as controls. CKD was defined as 24-hour urine protein (24-HUP) ≥0.3 g and/or glomerular filtration rate (GFR) < 60 ml/min. Subjects were recruited from the HIV clinic and the Medical Outpatient Department of Federal Medical Centre, Owerri. Clinical and anthropometric data were collected. Relevant investigations were performed, including HIV screening and relevant urine and blood investigations. The mean age of the HIV subjects was 38.84 ± 10.65 years. CKD was present in 86 (22.9%) HIV subjects and 11 (8.l %) controls. Low waist circumference (WC), high serum creatinine, high spot urine protein/creatinine ratio (SUPCR), high 24-HUP/creatinine Ratio (24-HUPCR), high 24-HUP/osmolality Ratio (24-HUPOR) predicted CKD in HIV subjects. CKD prevalence is high (22.9%) among newly diagnosed HIV patients in South East Nigeria. The predictors of CKD included WC, serum creatinine, SUPCR, 24-HUPCR, and 24-HUPOR.