Mortality in two cohorts of welders exposed to high- and low-levels of hexavalent chromium.
Mortality in two cohorts of welders exposed to high- and low-levels of hexavalent chromium.
复制标题
暴露于高浓度和低浓度六价铬的两组焊工的死亡率。
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Lars Hedstrom
中科院分区：
文献类型：
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作者：
Bengt Sjögren;Annika Gustavsson;Lars Hedstrom
不锈钢焊接过程中会产生六价铬颗粒。这些颗粒在细菌试验系统中表现出致突变作用，并在培养的中国仓鼠细胞中产生染色体畸变。选择了由234名从事不锈钢工作并暴露于高水平铬的焊工组成的队列。根据先前的调查，这些焊工的六价铬暴露量通常超过20微克/立方米。另一组由208名铁路轨道焊工暴露于低水平的铬也被选中。这两个队列的参与者在1950年至1965年之间的某个时间焊接了至少五年，并对死亡率进行了随访，直到1984年12月。在暴露于高铬水平的焊工中，有五人死于肺肿瘤。这一数字明显高于暴露于低水平铬的焊工中发生的死亡人数，但并不明显高于一般人群的相应死亡率。因此，暴露于不锈钢焊接烟雾可能与肺肿瘤的发病率增加。
Hexavalent chromium particles are generated in the welding of stainless steel. These particles have manifested a mutagenic action in bacterial test systems and produced chromosome aberrations in cultured Chinese hamster cells. A cohort consisting of 234 welders working on stainless steel and exposed to high levels of chromium was selected. According to an earlier survey the hexavalent chromium exposure of such welders was often above 20 micrograms/m3. Another cohort consisting of 208 railway track welders exposed to low levels of chromium was also selected. The participants of both cohorts had welded for at least five years some time between 1950 and 1965 and were followed for mortality until December 1984. Among the welders exposed to high chromium levels five deaths occurred due to pulmonary tumors. This number is significantly greater than the one death that occurred among the welders exposed to low levels of chromium, but not significantly greater than the corresponding mortality of the general population. Thus exposure to stainless steel welding fumes might be associated with an increased incidence of pulmonary tumors.
影响因子：
3.5
作者：
Selikoff,IJ;Nicholson,WJ;Lilis,R
通讯作者：
Lilis,R