First enantioselective total synthesis of (-)-heliannuol C
First enantioselective total synthesis of (-)-heliannuol C
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DOI：
10.1016/j.tetlet.2003.09.086
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发表时间：
2003-11-10
影响因子：
1.8
通讯作者：
Shishido, K
中科院分区：
文献类型：
--
作者：
Kamei, T;Shindo, M;Shishido, K
以6-对称二醇的化学酶去对称化、环合歧化、非对映选择性环氧化和环氧化物的区域选择性还原裂解为关键反应步骤，首次实现了(-)-茉莉醇C(1)的高效全合成。(C)2003爱思唯尔有限公司。保留所有权利。
The first, efficient total synthesis of (-)-heliannuol C (1) was accomplished enantioselectively, using a chemoenzymatic desymmetrization of the 6-symmetrical diol, a ring closing metathesis, a diastereoselective epoxidation, and a regioselective reductive cleavage of epoxide as the key reaction steps. (C) 2003 Elsevier Ltd. All rights reserved.