Preparation, microstructure and function of liposome with light responsive switch
Preparation, microstructure and function of liposome with light responsive switch
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光响应开关脂质体的制备、微观结构及功能
DOI：
10.1016/j.colsurfb.2018.10.068
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发表时间：
2019-06-01
影响因子：
5.8
通讯作者：
An, Xueqin
中科院分区：
文献类型：
--
作者：
Liu, Yangyang;An, Xueqin
采用薄膜水合和超临界二氧化碳技术相结合的方法制备了一种新型的光响应性脂质体。在脂质体中，姜黄素和4-butylazobenzene-4-hexyloxy-trimethyl-ammo-niumtrifluoro-acetate分别作为模型药物和光响应性可逆开关。利用脂质体的相变温度确定药物的最佳孵育温度。用透射电子显微镜和动态光散射技术观察脂质体的形态和大小。用荧光探针对脂质体的微观结构进行了研究，发现BHA以磷脂的极性基团包裹在脂质体的双层中。从微观结构和宏观性质两个方面研究了BHA在脂质体中的光响应性和可逆性。结果表明，BHA结构异构化的可逆性可作为控制药物释放的光响应开关。
A novel liposome with photo-responsiveness was prepared by a combined method of thin film hydration and supercritical carbon dioxide technique. In liposomes, curcumin and 4-butylazobenzene-4-hexyloxy-trimethyl-ammo-niumtrifluoro-acetate (BHA) were used as model drug and photo-responsive reversible switch, respectively. Optimum incubation temperature of drug was determined by using phase transition temperature of the liposomes. Morphology and size of liposomes were obtained by transmission electron microscope and dynamic light scattering technology. Microstructure of liposomes was explored by fluorescent probes, and it was found that the BHA was encapsulated in polar groups of phospholipid in the bilayer of liposomes. Light responsiveness and reversibility of BHA in liposomes were studied from the viewpoint of the microstructure and the macro property. It was shown that the reversibility of structural isomerization of BHA can be used as photo-responsive switch to control drug release.