The influence of maternal immunization on infant immune responses
The influence of maternal immunization on infant immune responses
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DOI：
10.1016/j.jcpa.2007.04.006
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发表时间：
2007-07-01
影响因子：
0.8
通讯作者：
Englund, J. A.
中科院分区：
文献类型：
--
作者：
Englund, J. A.
人类母亲孕期接种疫苗会导致抗体经胎盘转移，从而为新生儿早期提供保护。这种主动转移是受体介导的事件，通过FCR(N)受体优先转运IgG1和IgG3亚类的抗体。经胎盘移植的效率取决于一系列因素，包括：胎盘完整性、孕妇血液中的总免疫球蛋白浓度、疫苗的类型、孕期接种疫苗的时间、胎儿出生时的孕周以及所涉及的免疫球蛋白亚类。以乙型流感嗜血杆菌(Hib)疫苗接种为模型，对母婴血清学反应动力学进行了广泛研究。(C)2007爱思唯尔有限公司。保留所有权利。
The vaccination of human mothers during pregnancy leads to transplacental transfer of antibody which can provide protection to the neonate during early life. This active transfer is a receptor-mediated event with preferential transport of antibody of the IgG1 and IgG3 subclasses via the FcR(n) receptor. The efficiency of trans-placental transfer is dependent on a range of factors including: placental integrity, the total IgG concentration in maternal blood, the type of vaccine, the timing of vaccine administration during gestation, the gestational age of the fetus at birth and the IgG subclass involved. The kinetics of maternal and infant serological responses has been extensively studied using Haemophilus influenzae b (Hib) vaccination as a model. (c) 2007 Elsevier Ltd. All rights reserved.