Thyroid hormone supplementation in sepsis: An experimental study
Thyroid hormone supplementation in sepsis: An experimental study
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DOI：
10.1007/s005950300004
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发表时间：
2003-01-01
期刊：
影响因子：
2.5
通讯作者：
Sen, M
中科院分区：
文献类型：
--
作者：
Inan, M;Koyuncu, A;Sen, M
目的。甲状腺激素水平在脓毒症、危重症和预后不良的严重创伤患者中降低。本研究旨在探讨补充甲状腺激素对脓毒症标准和脓毒症模型死亡率的影响。48只wistar - albin病大鼠分为4个实验组。采用盲肠结扎穿刺作为脓毒症模型。第一组：假手术；II组：盲肠结扎穿刺（对照组）；III组：盲肠结扎穿刺+腹腔内T3（0.4杯/100g体重/天）；IV组：盲肠结扎穿刺+T4肌注（1500ng/100g体重/天）。评估各组的二氧化碳分压、白细胞计数、腹膜细菌含量、中性粒细胞减少和死亡率。PCO2水平仅在对照组降低（P < 0.05）。治疗组白细胞计数明显低于对照组（P < 0.05）。对照组中性粒细胞减少率明显高于对照组（P < 0.05）。各治疗组腹腔细菌含量明显降低（P < 0.05）。甲状腺激素组动物死亡率显著降低（P < 0.05）。在脓毒症大鼠中补充甲状腺激素对脓毒症标准有有益的影响，也导致较低的死亡率。
Purpose. The levels of thyroid hormones decrease in septic, critically ill, and major trauma patients who show a bad prognosis. The aim of this study was to investigate the effects of thyroid hormone supplementation on the sepsis criteria and mortality in an experimental sepsis model.Methods. Forty-eight Wistar-Albino rats were divided into four experimental groups. A cecum ligation and puncture was used as a sepsis model. Group I: sham; group II: a cecum ligation and puncture (control); group III: a cecum ligation and puncture +T3 (0.4 mug/100g body weight/day) intraperitoneally; group IV: a cecum ligation and puncture +T4 (1500ng/100g body weight/day) intramuscularly. The PCO2, leukocyte count, peritoneal bacterial content, neutropenia, and mortality rates were assessed in all groups.Results. The PCO2 levels decreased only in the control group (P < 0.05). The leukocyte counts were lower in the therapy groups (P < 0.05). The rate of neutropenia was seen much more in the control group (P < 0.05). The peritoneal bacteria content decreased in the therapy groups (P < 0.05). The mortality rate significantly decreased in the thyroid hormone-treated animals (P < 0.05).Conclusions. Thyroid hormone supplementation in septic rats had a beneficial effect on the sepsis criteria and also resulted in a lower rate of mortality.