Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors
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DOI：
10.1016/j.bmcl.2006.05.091
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发表时间：
2006-08-15
影响因子：
2.7
通讯作者：
Natsugari, Hideaki
中科院分区：
文献类型：
--
作者：
Fuwa, Haruhiko;Hiromoto, Kenichi;Natsugari, Hideaki
本文介绍了一类芳基磺酰胺类伽玛分泌酶抑制剂的合成和生物学评价。还报道了以二苯甲酮为交联基和生物素标记的多功能分子探针的设计、合成和生物学评价。(C)2006爱思唯尔有限公司。保留所有权利。
Synthesis and biological evaluation of an arylsulfonamide class of gamma-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported. (c) 2006 Elsevier Ltd. All rights reserved.