Immunity in the brain and surrounding tissues.
Immunity in the brain and surrounding tissues.
复制标题
大脑和周围组织的免疫力。
DOI：
10.1093/jb/mvad010
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ito M.
中科院分区：
文献类型：
--
作者：
Kanamori M;Ito M.
大脑的免疫反应是最复杂的器官，它直接或间接地调节着身体的几乎每一个部分及其活动，需要严格调节。神经免疫学领域的最新发现增强了我们对免疫细胞的认识，不仅在大脑内部，而且在邻近组织中。多种类型的免疫细胞存在并在邻近的边界组织中活跃，即使在稳定状态下也是如此。此外，技术的进步使研究人员能够表征广泛的细胞类型，包括支持免疫反应的基质细胞。这篇综述简要介绍了免疫系统在健康和疾病期间在大脑中的作用，重点是适应性免疫和作用的解剖部位。我们还讨论了基质细胞的潜在作用。
Immune reactions in the brain, the most complex organ that directly or indirectly regulates almost every part of the body and its actions, need to be tightly regulated. Recent findings in the field of neuroimmunology have enhanced our understanding of immune cells not only inside the brain but also in adjacent tissues. Multiple types of immune cells exist and are active in neighboring border tissues, even in the steady state. In addition, advances in technology have allowed researchers to characterize a broad range of cell types, including stromal cells that support immune reactions. This review presents a short overview of the roles of the immune system in the brain during health and disease, with focus on adaptive immunity and anatomical sites of action. We also discuss potential roles of stromal cells.