Seroprevalence and ethnic differences in Helicobacter pylori infection among adults in the United States
Seroprevalence and ethnic differences in Helicobacter pylori infection among adults in the United States
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DOI：
10.1086/315384
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发表时间：
2000-04-01
影响因子：
6.4
通讯作者：
McQuillan, G
中科院分区：
文献类型：
--
作者：
Everhart, JE;Kruszon-Moran, D;McQuillan, G
幽门螺杆菌感染的血清阳性率在美国成年人群和不同种族人群中进行了检查。用敏感、特异的IgG ELISA法检测了1988-1991年第三次全国健康与营养调查第一阶段7465例成人血清标本。H. pylori感染率为32.5%。这一比例随着年龄的增长而上升，从20-29岁的16.7%上升到70岁以上的56.9%。非西班牙裔黑人（52.7%）和墨西哥裔美国人（61.6%）中的非西班牙裔校正患病率显著高于非西班牙裔白人（26.2%）。在控制了年龄和其他相关因素后，非西班牙裔黑人相对于非西班牙裔白人的优势比从3.9（95%置信区间[CI]，3.1-4.9）至3.3（95% CI，2.6-4.2），墨西哥裔美国人为6.3（95% CI，4.8-8.3）至2.3（95% CI，1.6-3.5）。H.非西班牙裔黑人和墨西哥裔美国人中的幽门螺杆菌感染部分由与感染相关的其他因素解释。
The seroprevalence of Helicobacter pylori infection was examined in the adult US population and among different ethnic groups. Stored sera from 7465 adult participants in the first phase of the third National Health and Nutritional Examination Survey (1988-1991) were tested with a sensitive and specific IgG ELISA, to diagnose infection. Seroprevalence of H. pylori among all participants was 32.5%. This increased with age, from 16.7% for persons 20-29 years old to 56.9% for those greater than or equal to 70 years old. Age-adjusted prevalence was substantially higher among non-Hispanic blacks (52.7%) and Mexican Americans (61.6%) than among non-Hispanic whites (26.2%). After controlling for age and other associated factors, the odds ratios relative to non-Hispanic whites decreased for non-Hispanic blacks, from 3.9 (95% confidence interval [CI], 3.1-4.9) to 3.3 (95% CI, 2.6-4.2), and for Mexican Americans, from 6.3 (95% CI, 4.8-8.3) to 2.3 (95% CI, 1.6-3.5). The high prevalence of H. pylori infection among non-Hispanic blacks and Mexican Americans is partially explained by other factors associated with infection.