Liver fat content and T2*: Simultaneous measurement by using breath-hold multiecho MR imaging at 3.0 T - Feasibility
Liver fat content and T2*: Simultaneous measurement by using breath-hold multiecho MR imaging at 3.0 T - Feasibility
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DOI：
10.1148/radiol.2472070880
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发表时间：
2008-05-01
期刊：
影响因子：
19.7
通讯作者：
Schmitz, Stephan A.
中科院分区：
文献类型：
--
作者：
O'Regan, Declan P.;Callaghan, Martina F.;Schmitz, Stephan A.
本研究获得了研究伦理委员会的批准，并获得了所有参与者的书面知情同意书。目的是前瞻性评价屏气多回波同相和异相磁共振（MR）成像用于同时进行脂质定量和T2* 测量的可行性。在3.0 T下使用了一个扰相梯度回波序列，其中7个回波时间交替同相和异相。成像在脂质体模中进行，在5名健康志愿者（均为男性;平均年龄，37岁）和5名患有高脂血症或糖尿病的肥胖个体（4名男性，1名女性;平均年龄，53岁）。一个双指数曲线拟合模型被用来获得脂肪和水的相对信号的贡献，这些结果进行了比较，与肝脏质子磁共振波谱，参考标准的结果。多回波法与光谱法测定肝脏脂质浓度有显著相关性（r（2）= 0.99，P
Research ethics committee approval was obtained for this study, and written informed consent was obtained from all participants. The purpose was to prospectively evaluate the feasibility of breath-hold multiecho in- and out-of-phase magnetic resonance (MR) imaging for simultaneous lipid quantification and T2* measurement. A spoiled gradient-echo sequence with seven echo times alternately in phase and out of phase was used at 3.0 T. Imaging was performed in a lipid phantom, in five healthy volunteers ( all men; mean age, 37 years), and in five obese individuals with hyperlipidemia or diabetes ( four men, one woman; mean age, 53 years). A biexponential curve-fitting model was used to derive the relative signal contributions from fat and water, and these results were compared with results of liver proton MR spectroscopy, the reference standard. There was a significant correlation between multiecho and spectroscopic measurements of hepatic lipid concentration ( r(2) = 0.99, P