Impaired interhemispheric interactions in patients with major depression
Impaired interhemispheric interactions in patients with major depression
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DOI：
10.1097/nmd.0b013e318183f86f
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发表时间：
2008-09-01
影响因子：
1.9
通讯作者：
Fregni, Felipe
中科院分区：
文献类型：
--
作者：
Bajwa, Sami;Bermpohl, Felix;Fregni, Felipe
以往的研究表明，抑郁症患者存在左右侧前额叶和运动皮层的半球间不平衡。我们的目的是研究使用重复经颅磁刺激（rTMS）的抑郁症患者的大脑半球间的相互作用。13例重性抑郁症患者和14名年龄匹配的健康受试者参加了这项研究。皮质脊髓兴奋性之前和之后的1 Hz rTMS（适用于左侧初级运动皮层）进行了评估，在左侧和右侧运动皮层，这些结果与健康受试者进行了比较。抑郁症患者和健康人的大脑半球间效应存在显著性差异。在健康受试者中，1 Hz rTMS显着降低皮质脊髓兴奋性的刺激，左半球和增加它在对侧，右半球。在抑郁症患者中，1 Hz rTMS也降低了左半球的皮质脊髓兴奋性;然而，它没有引起对侧右半球皮质脊髓兴奋性的显着变化。此外，有一个显着的相关性，大脑半球间的调制程度和抑郁症的严重程度指数贝克抑郁症量表得分。我们的研究结果显示，抑郁症患者的大脑半球间调制减少，这与心境障碍与大脑半球间缓慢转换机制有关的观点一致。
Previous studies have shown that patients with major depression have an interhemispheric imbalance between right and left prefrontal and motor cortex. We aimed to investigate the interhemispheric interactions in patients with major depression using repetitive transcranial magnetic stimulation (rTMS). Thirteen patients with major depression and 14 age-matched healthy subjects participated in this study. Corticospinal excitability before and after 1 Hz rTMS (applied to the left primary motor cortex) was assessed in the left and right motor cortex and these results were compared with those in healthy subjects. There was a significant difference in the interhemispheric effects between patients with depression and healthy subjects. In healthy subjects, 1 Hz rTMS significantly decreased corticospinal excitability in the stimulated, left hemisphere and increased it in the contralateral, right hemisphere. In depressed subjects, 1 Hz rTMS also decreased corticospinal excitability in the left hemisphere; however, it induced no significant changes in corticospinal excitability in the contralateral, right hemisphere. In addition, there was a significant correlation between the degree of interhemispheric modulation and the severity of the depression as indexed by the Beck Depression Inventory scores. Our findings showing a decreased interhemispheric modulation in patients with major depression are consistent with the notion that mood disorders are associated with slow interhemispheric switching mechanisms.