Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia
Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia
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DOI：
10.1192/bjp.bp.105.016998
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发表时间：
2006-10-01
影响因子：
10.5
通讯作者：
Tsuang, Ming T.
中科院分区：
文献类型：
--
作者：
Glatt, Stephen J.;Stone, William S.;Tsuang, Ming T.
背景 对精神分裂症高遗传风险个体的评估是识别疾病前兆的有力方法。目的 确定区分高危个体和对照个体的人格、精神病理学和社会发展方面。方法 对精神分裂症或分裂情感性障碍患者的青少年和青年一级亲属 (n=35) 和对照组 (n=55) 在纵向研究基线时的 36 项测量进行比较区分高风险参与者和对照参与者与四个基因负荷指数有关。结果 17 岁以上的高风险参与者表现出更多的身体快感缺失，与同龄人的积极参与程度较低，以及与同龄人、兄弟姐妹和异性之间的问题更多。年龄较大的高风险个体也不太合作、不太自我指导、不太依赖奖励。与同龄人和异性之间的问题以及奖励依赖与遗传负荷呈线性相关。结论 高风险个体中存在人格特征和社会发展的改变，并且可能是该疾病的遗传倾向的标志。
Background Evaluation of individuals at high genetic risk of schizophrenia is a powerful method for identifying precursors of the illness.Aims To identify aspects of personality, psychopathology and social development that differentiate high-risk and control individuals.Method Adolescent and young-adult first-degree relatives (n=35) of people with schizophrenia or schizoaffective disorder and a control group (n=55) were compared on 36 measures at baseline of a longitudinal study Measures differentiating high-risk and control participants were related to four genetic loading indices.Results High-risk participants older than 17 years showed more physical anhedonia, less positive involvement with peers and more problems with peers, siblings and the opposite gender. Older high-risk individuals also were less cooperative, less self-directed and less reward-dependent. Problems with peers and the opposite gender, as well as reward dependence, were related linearly to genetic loading.Conclusions Alterations in personality traits and social development are present in high-risk individuals, and may be markers for genetic liability toward the illness.