Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach
Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach
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DOI：
10.1183/13993003.02127-2015
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发表时间：
2017-01-01
影响因子：
24.3
通讯作者：
Hodgson, Susan
中科院分区：
文献类型：
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作者：
Cai, Yutong;Zijlema, Wilma L.;Hodgson, Susan
我们使用2006-2013年建立的三项欧洲队列研究的协调数据，研究了环境空气污染和交通噪音对成人哮喘患病率的影响（Hunt3，住宅暴露于环境空气污染（空气动力学直径为20年的颗粒物），使用DataSHIELD汇集数据，通过“计算数据”进行个人层面的分析approach.拟合多变量逻辑回归模型以评估每种暴露对终生和当前哮喘患病率的影响。PM10或NO2高10 μ g中心点m-3分别与终生哮喘患病率高12.8%（95%CI 9.5-16.3%）和1.9%（95%CI 1.1-2.8%）相关，与混杂因素无关。对老年人的影响更大。50年来，吸烟者和受教育程度较低。噪声暴露与哮喘患病率无显著相关性。这项研究表明，长期环境PM10暴露与西欧成年人哮喘患病率相关。交通噪声与哮喘患病率无关，但其对哮喘急性发作的潜在影响需要进一步研究。
We investigated the effects of both ambient air pollution and traffic noise on adult asthma prevalence, using harmonised data from three European cohort studies established in 2006-2013 (HUNT3, Lifelines and UK Biobank).Residential exposures to ambient air pollution (particulate matter with aerodynamic diameter = 20 years was undertaken using DataSHIELD to pool data for individual-level analysis via a "compute to the data" approach. Multivariate logistic regression models were fitted to assess the effects of each exposure on lifetime and current asthma prevalence.PM10 or NO2 higher by 10 mu g center dot m-3 was associated with 12.8% (95% CI 9.5-16.3%) and 1.9% (95% CI 1.1-2.8%) higher lifetime asthma prevalence, respectively, independent of confounders. Effects were larger in those aged. 50 years, ever-smokers and less educated. Noise exposure was not significantly associated with asthma prevalence.This study suggests that long-term ambient PM10 exposure is associated with asthma prevalence in western European adults. Traffic noise is not associated with asthma prevalence, but its potential to impact on asthma exacerbations needs further investigation.