The effect of agitated drying on the morphology of L-threonine (needle-like) crystals
The effect of agitated drying on the morphology of L-threonine (needle-like) crystals
复制标题
DOI：
10.1016/j.ijpharm.2003.10.022
复制
发表时间：
2004-02-11
影响因子：
5.8
通讯作者：
Glasser, BJ
中科院分区：
文献类型：
--
作者：
Lekhal, A;Girard, KP;Glasser, BJ
本文对L-苏氨酸针状晶体在搅拌干燥过程中的行为进行了实验研究。对于L-苏氨酸/水体系，使用光学显微镜和图像分析监测晶体的形态。对晶体尺寸和形状分布的瞬态行为的分析表明，在该过程中，磨损和团聚同时发生。操作条件（温度，搅拌和真空）的变化表明，当干燥速率低和/或剪切速率高时，磨损占主导地位的干燥过程。对于高干燥速率和低剪切速率，团聚成为主导。该研究表明，晶体再溶解对晶体形态没有显著影响。还发现，由于它们的针状形状，大的L-苏氨酸晶体对磨损非常敏感。当研磨控制干燥过程时，大部分粒度减小发生在低于4%的临界含水量。当附聚控制干燥过程时，大部分晶体尺寸增大发生在低于6%的水分含量下。(C)2003 Elsevier B. V.保留所有权利。
Experiments have been carried out to study the behavior Of L-threonine (needle-like) crystals during agitated drying. For an L-threonine/water system the morphology of the crystals was monitored using light microscopy and image analysis. Analysis of the transient behavior of the crystal size and shape distribution showed that attrition and agglomeration took place simultaneously during the process. The variation of the operating conditions (temperature, agitation and vacuum) revealed that attrition dominated the drying process when the drying rate was low and/or the shear rate was high. For high drying rates and low shear rates, agglomeration became dominant. This study suggests that crystal redissolution had no significant impact on crystal morphology. It was also found that due to their needle-like shape, large L-threonine crystals were very sensitive to attrition. When attrition controlled the drying process, most of the particle size reduction took place below a critical moisture content of 4%. When agglomeration controlled the drying process, most of the crystal size enlargement occurred below a moisture content of 6%. (C) 2003 Elsevier B.V. All rights reserved.