High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
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DOI：
10.1289/ehp.6220
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发表时间：
2003-07
影响因子：
10.4
通讯作者：
Charles, M Judith
中科院分区：
文献类型：
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作者：
Petreas, Myrto;She, Jianwen;Brown, F Reber;Winkler, Jennifer;Windham, Gayle;Rogers, Evan;Zhao, Guomao;Bhatia, Rajiv;Charles, M Judith
在我们的第一份关于加利福尼亚妇女多溴联苯醚（PBDE）浓度升高的报告之后，我们扩大了我们的调查，包括不同群体的当地妇女。我们分析了20世纪90年代末从旧金山湾区参与乳腺癌研究和生殖研究的妇女中收集的额外脂肪和血清样本。脂肪样品（n = 32）采用低分辨率质谱法进行负离子化学电离分析，血清样品（n = 50）采用双柱气相色谱法进行电子捕获检测。结果证实了我们早先的发现。2,2,4,4 -四溴联苯醚（BDE-47）在当代加利福尼亚妇女中的浓度范围在5至510 ng/g脂质之间，中位数（16.5 ng/g脂质）比欧洲报告的浓度高3-10倍。相比之下，在20世纪60年代从旧金山湾区参与儿童发育研究的妇女中收集的420份存档血清样本中，多溴二苯醚没有任何可测量到。BDE-47浓度不随年龄或多氯联苯（PCB-153）浓度的增加而增加，这表明除了饮食外还有其他接触途径。多溴二苯醚等干扰内分泌的化学物质的身体负担不断增加，可能对公众健康构成潜在威胁。
Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breast cancer study and in a reproductive study, respectively. Adipose samples (n = 32) were analyzed by low-resolution mass spectrometry in negative-ion chemical ionization mode, whereas serum samples (n = 50) were analyzed by dual-column gas chromatography with electron capture detection. The results confirmed our earlier findings. Concentrations of 2,2,4,4 -tetrabromodiphenyl ether (BDE-47) in contemporary California women ranged between 5 and 510 ng/g lipid, with a median (16.5 ng/g lipid) 3-10 times higher than those reported from Europe. In contrast, PBDEs were not measurable in any of 420 archived serum samples collected in the 1960s from San Francisco Bay Area women participating in a study of child development. BDE-47 concentrations did not increase with age or with concentrations of a polychlorinated biphenyl (PCB-153), suggesting other routes of exposure in addition to diet. Rising body burdens of endocrine-disrupting chemicals such as PBDEs may pose a potential public health threat.