VINIGROL, A NOVEL ANTIHYPERTENSIVE AND PLATELET-AGGREGATION INHIBITORY AGENT PRODUCED BY A FUNGUS, VIRGARIA-NIGRA .2. PHARMACOLOGICAL CHARACTERISTICS
VINIGROL, A NOVEL ANTIHYPERTENSIVE AND PLATELET-AGGREGATION INHIBITORY AGENT PRODUCED BY A FUNGUS, VIRGARIA-NIGRA .2. PHARMACOLOGICAL CHARACTERISTICS
复制标题
DOI：
10.7164/antibiotics.41.31
复制
发表时间：
1988-01-01
影响因子：
3.3
通讯作者：
OKUHARA, M
中科院分区：
文献类型：
--
作者：
ANDO, T;YOSHIDA, K;OKUHARA, M
Vinigrol，一种新的二萜类化合物，由紫藤产生，口服清醒的自发性高血压大鼠（SHR），以确认其抗高血压活性。Vinigrol（2 mg/kg，po）使SHR的平均动脉血压降低约15%，持续至少6小时。Vinigrol诱导大鼠主动脉平滑肌制备物在1.5 ×10-7 M，收缩被尼伐地平（一种Ca ~（2+）内流阻断剂）阻断，但不被哌唑嗪或育亨宾抑制。α的放射性受体结合测定大鼠脑膜肾上腺素能受体的测定结果表明，长春尼酚对这些受体无亲和力。
Vinigrol, a novel diterpene produced by Virgaria nigra, was tested orally in conscious spontaneously hypertensive rats (SHR) to confirm its antihypertensive activity. Vinigrol (2 mg/kg, po) decreased the mean arterial blood pressure of SHR by approximately 15% for at least 6 hours. Vinigrol induced contraction of rat aortic smooth muscle preparation at 1.5 .times. 10-7 M, the contraction was blocked by nilvadipine, a Ca2+ entry blocker, but was not inhibited by prazosin or yohimbine. Radio-receptor binding assay of .alpha. adrenoceptors of rat brain membrane revealed that vinigrol had no affinity for these receptors.