THE INDUCTION OF ADENOCARCINOMATOUS DIFFERENTIATION IN NEOPLASTIC BLADDER EPITHELIUM BY AN EMBRYONIC PROSTATIC INDUCTOR
THE INDUCTION OF ADENOCARCINOMATOUS DIFFERENTIATION IN NEOPLASTIC BLADDER EPITHELIUM BY AN EMBRYONIC PROSTATIC INDUCTOR
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DOI：
10.1016/s0022-5347(17)53221-8
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发表时间：
1982-01-01
影响因子：
6.6
通讯作者：
NORMAN, JT
中科院分区：
文献类型：
--
作者：
FUJII, H;CUNHA, GR;NORMAN, JT
将取自大鼠膀胱的非腺性移行细胞癌上皮细胞与胚胎大鼠泌尿生殖窦间充质细胞(一种前列腺癌诱导剂)复合后移植到同基因成年雄性宿主体内。肿瘤膀胱上皮在大量重组体中形成腺(腺癌)腺泡，提示间充质(间质)可能影响癌细胞的组织类型，诱导肿瘤上皮表达一种新的表型。
Epithelial cells of non-glandular, transitional cell carcinomas from rat urinary bladders were associated with embryonic rat urogenital sinus mesenchyme (a prostatic inductor) and transplanted into syngeneic adult male hosts. Neoplastic bladder epithelium formed glandular (adenocarcinomatous) acini in a substantial number of recombinants, suggesting that the mesenchyme (stroma) may influence the histotypic organization of carcinoma cells and induce the neoplastic epithelium to express a novel phenotype.