LP(A) LIPOPROTEIN AS A RISK FACTOR FOR CORONARY HEART-DISEASE AND CEREBRAL INFARCTION
LP(A) LIPOPROTEIN AS A RISK FACTOR FOR CORONARY HEART-DISEASE AND CEREBRAL INFARCTION
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DOI：
10.1016/0021-9150(86)90048-1
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发表时间：
1986-02-01
期刊：
影响因子：
5.3
通讯作者：
KAMEYAMA, M
中科院分区：
文献类型：
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作者：
MURAI, A;MIYAHARA, T;KAMEYAMA, M
我们试图制备Lp(A)脂蛋白的单特异性抗血清，并根据日本正常人和冠心病或脑梗塞患者的血浆Lp(A)水平来研究受试者的分布。(1)日本健康受试者Lp(A)(Ouchterlony)双扩散试验的阳性血浆反应率为32.3%，与西方国家报道的结果相似。(2)根据双扩散试验的反应将受试者分为阳性组和阴性组，17 mg/dl的血浆阈值水平是合适的临界点。(3)当受试者按17 mg/dl分成两组时，血浆Lp(A)水平升高与冠心病或脑梗塞的皮质动脉分布显著相关。提示Lp(A)可能是冠心病和脑梗塞的危险因素之一。
Attempts were made to prepare antisera monospecific for Lp(a) lipoprotein and to investigate the distribution of subjects according to plasma levels of Lp(a) in Japanese controls and patients with coronary heart disease or cerebral infarction. (1) Positive plasma reactions to the double diffusion test for Lp(a) (Ouchterlony) were observed in 32.3% of the healthy Japanese subjects, which is similar to results previously reported in western countries. (2) The plasma threshold level of 17 mg/dl was considered an appropriate point for dividing subjects into positive and negative groups depending on reactions to the double diffusion test. (3) When subjects were divided into two groups at 17 mg/dl, a significant association was found between a high plasma level of Lp(a) and either coronary heart disease or cerebral infarction in the distribution of the cortical artery. These results suggest that Lp(a) may play an important part as a risk factor for coronary heart disease and cerebral infarction.