HIV type 1 isolates from 200 untreated individuals in Ho Chi Minh City (Vietnam):: ANRS 1257 study.: Large predominance of CRF01_AE and presence of major resistance mutations to antiretroviral drugs
HIV type 1 isolates from 200 untreated individuals in Ho Chi Minh City (Vietnam):: ANRS 1257 study.: Large predominance of CRF01_AE and presence of major resistance mutations to antiretroviral drugs
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DOI：
10.1089/088922203322493111
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发表时间：
2003-10-01
影响因子：
1.5
通讯作者：
Fleury, HJ
中科院分区：
文献类型：
--
作者：
Nguyen, THL;Recordon-Pinson, P;Fleury, HJ
对2001年和2002年在越南南部，特别是胡志明市招募的200名未经治疗的患者的HIV-1分离株进行RT、蛋白酶和env基因测序。在200株分离株中，有198株属于CRF 01_ AE，而仅观察到1株B亚型和1株亚型间重组体（B-CRF 01_AE）。6.5%的分离株对抗逆转录病毒药物具有主要耐药突变。
HIV-1 isolates from 200 untreated patients recruited in 2001 and 2002 in the south part of Vietnam and particularly in Ho Chi Minh City were sequenced in the RT, protease, and env genes. Out of 200 isolates 198 belonged to CRF01_ AE while only one subtype B and one intersubtype (B-CRF01_AE) recombinant could be observed. Of the isolates 6.5% had major resistance mutations to antiretroviral drugs.