Characteristics of renal sympathetic nerve activity in sodium-retaining disorders.
Characteristics of renal sympathetic nerve activity in sodium-retaining disorders.
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DOI：
10.1152/ajpregu.1996.271.1.r295
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发表时间：
1996-07
期刊：
影响因子：
--
通讯作者：
G. Dibona;L. Sawin;S. Jones
中科院分区：
文献类型：
--
作者：
G. Dibona;L. Sawin;S. Jones
建立充血性心力衰竭，肝硬化，肾病综合征清醒大鼠肾交感神经活动的特点进行了分析，使用三种方法：平均积分电压随时间的推移，功率谱分析，和交感神经峰检测分析。与对照组相比，三种疾病模型的平均积分电压均升高。功率谱分析显示，三种疾病模型在心率频率处的相对功率均增加，表明其与肾交感神经放电与心动周期的耦合有关。充血性心力衰竭和肾病综合征大鼠在低频范围内表现出增加的相对功率，而肾病综合征大鼠在高频范围内表现出降低的相对功率。在交感神经峰检测分析中，与对照组相比，三种疾病模型中的交感神经峰的频率更高。在强直性脊柱炎大鼠中，交感神经峰高度的分布向高度较小的峰的数量增加的方向移动。可以得出结论，在这些疾病模型中，基础肾交感神经活动慢性增加。这表现为与心动周期相关的功率增加，这可能反映了动脉和心脏压力反射控制中的疾病特异性缺陷。在肝硬化中，可能存在肾交感神经纤维亚群的选择性激活。
Characteristics of renal sympathetic nerve activity in conscious rats with established congestive heart failure, cirrhosis, or nephrotic syndrome were analyzed using three methods: mean integrated voltage over time, power spectrum analysis, and sympathetic peak detection analysis. Compared with control rats, all three disease models had increased mean integrated voltage. On power spectrum analysis, all three disease models had increased relative power at the heart rate frequency, indicating that it was related to renal sympathetic nerve discharge coupled to the cardiac cycle. Congestive heart failure and nephrotic syndrome rats showed increased relative power in the low-frequency range, whereas cirrhotic and nephrotic syndrome rats showed decreased relative power in the high-frequency range. On sympathetic peak detection analysis, the frequency of sympathetic peaks was greater in the three disease models compared with the control rats. In cirrhotic rats, the distribution of sympathetic peak heights was shifted toward an increased number of peaks of lesser height. It is concluded that basal renal sympathetic nerve activity is chronically increased in these disease models. This is manifest as increased power coupled to the cardiac cycle, which may reflect the disease-specific defects in arterial and cardiac baroreflex control. In cirrhosis, there is possible selective activation of a subgroup of renal sympathetic nerve fibers.