The minimum number of genes contributing to quantitative variation between and within populations.
The minimum number of genes contributing to quantitative variation between and within populations.
复制标题
导致群体之间和群体内数量变异的基因的最小数量。
DOI：
10.1093/genetics/99.3-4.541
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发表时间：
1981
期刊：
影响因子：
3.3
通讯作者：
Lande,R
中科院分区：
文献类型：
--
作者：
Lande,R
概述了估计自由分离遗传因子的最小数量 nE 的程序，该因子有助于通过人工或自然选择分化的两个群体之间的数量特征差异。如果在适当的测量范围上大致满足某些简单标准，则可以通过比较两个亲本群体及其F1和F2杂种（和回交）的表型平均值和方差来估计nE。这概括了 WRIGHTTo 遗传异质（或野生）亲本群体以及近交系的方法。估计值的标准误差是针对大样本得出的。导致群体之间数量性状产生巨大差异的基因的最小数量通常估计约为 5 或 10，偶尔可达 20。这有力地支持了新达尔文理论，即大的进化变化通常是通过影响相对较小的多个遗传因素的积累而发生的。
A procedure is outlined for estimating the minimum number of freely segregating genetic factors,nE,contributing to the difference in a quantitative character between two populations that have diverged by artificial or natural selection. If certain simple criteria are satisfied approximately on an appropriate scale of measurement,nEcan be estimated by comparing the phenotypic means and variances in the two parental populations and in their F1and F2hybrids (and backcrosses). This generalizes the method of WRIGHtTo genetically heterogeneous (or wild) parental populations, as well as inbred lines. Standard errors of the estimates are derived for large samples. The minimum number of genes involved in producing a large difference between populations in a quantitative trait is typically estimated to be about 5 or IO, with occasional values up to 20. This strongly supports the neo-Darwinian theory that large evolutionary changes usually occur by the accumulation of multiple genetic factors with relatively small effects.